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Showing 1–2 of 2 results
Advanced filters: Author: Subhasree Balakrishnan Clear advanced filters

  • The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia.

    • Gina M. Sizemore
    • Subhasree Balakrishnan
    • Michael C. Ostrowski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Initially identified more than 30 years ago, the ETS family of transcription factors has been found to take part in all steps of tumorigenesis. This Review discusses the different mechanisms of ETS activation and the oncogenic implications of this activation, as well as how to target ETS factors in cancer treatment.

    • Gina M. Sizemore
    • Jason R. Pitarresi
    • Michael C. Ostrowski
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 337-351