NF-κB has largely been known as a transcriptional activator. Here the authors show that a transcriptionally repressive NF-κB complex, HDAC4–RelB–p52, maintains repressive chromatin at proapoptotic genes Bim and BMF, and regulates multiple myeloma survival and growth in an ERK1 dependent manner.
- Subrahmanya D. Vallabhapurapu
- Sunil K. Noothi
- Sivakumar Vallabhapurapu
