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Advanced filters: Author: Sudheer Dhanireddy Clear advanced filters

  • Small-molecule compounds that target the BET domain in proteins such as BRD4 have recently been identified as potential anticancer agents; here, the efficacy of the BRD4-targeting compound JQ1 is demonstrated in castration-resistant prostate cancer driven by deregulated androgen receptor action.

    • Irfan A. Asangani
    • Vijaya L. Dommeti
    • Arul M. Chinnaiyan
    Research
    Nature
    Volume: 510, P: 278-282