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Showing 1–9 of 9 results
Advanced filters: Author: Suhasini Joshi Clear advanced filters

  • Epichaperomics allow the study of protein-protein interactions and their alterations, but probes have been limited to capturing HSP90 epichaperomes. Here, the authors introduce and validate a toolset of HSP70 epichaperome ligands, and use them in epichaperomics to identify a mechanism with which cancer cells can enhance the fitness of mitotic protein networks.

    • Anna Rodina
    • Chao Xu
    • Gabriela Chiosis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-26

  • The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunction that can be corrected by novel therapeutics.

    • Maria Carmen Inda
    • Suhasini Joshi
    • Gabriela Chiosis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19

  • Here, the authors show structural, biochemical, and functional insights into the discovery of epichaperome‐ directed chemical probes for use in central nervous system diseases. Probes emerging from this work have translated to human clinical studies in Alzheimer’s disease and cancer.

    • Alexander Bolaender
    • Danuta Zatorska
    • Gabriela Chiosis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Renally clearable gold quantum clusters that are stabilized by the milk metalloprotein alpha-lactalbumin and display multicolour fluorescence aid the detection, resection and treatment of breast cancer in mice.

    • Jiang Yang
    • Tai Wang
    • Moritz F. Kircher
    Research
    Nature Biomedical Engineering
    Volume: 4, P: 686-703

  • The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain molecular level insight into the events induced by toxic and genetic stresses that mimic those occurring during neurodegeneration.

    • Sarah Kishinevsky
    • Tai Wang
    • Lorenz Studer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAPK-pathways and PI3K-mTOR pathway. To achieve this, the authors employ chemical modulation of the interactome via epichaperome inhibition with the small molecule PU-H71.

    • Suhasini Joshi
    • Erica DaGama Gomes
    • Gabriela Chiosis
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-20

  • In this Opinion, Joshi et al. argue that in cancer cells, a state of chaperome hyperconnectivity is obtained by increasing the interaction strength among chaperome machinery members. These chaperome scaffolding platforms act to increase the functional diversity of oncogenic processes and have implications for the development of chaperome inhibitors.

    • Suhasini Joshi
    • Tai Wang
    • Gabriela Chiosis
    Reviews
    Nature Reviews Cancer
    Volume: 18, P: 562-575