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Showing 1–2 of 2 results
Advanced filters: Author: Sujana Movva Clear advanced filters

  • The activity of PD-1 blockade in patients with sarcoma has been modest so far. Here, the authors report the results of a pilot clinical trial to assess the efficacy and safety of bempegaldesleukin, a CD122-preferential interleukin-2 (IL-2) pathway agonist, in combination with the PD1 blockade (nivolumab) in patients with locally advanced or metastatic high-grade sarcoma.

    • Sandra P. D’Angelo
    • Allison L. Richards
    • William D. Tap
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencing and find genomic groups that are distinct from histological subgroups.

    • Benjamin A. Nacev
    • Francisco Sanchez-Vega
    • William D. Tap
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15