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Showing 1–2 of 2 results
Advanced filters: Author: Sujanitha Umamaheswaran Clear advanced filters

  • The efficacy of antiangiogenic therapy in the clinic is often limited by the emergence of resistance. Here, the authors show that in ovarian cancer anti-VEGF inhibitors induce the overexpression of CD5L in endothelial cells through hypoxia-driven PPARy activation and that blocking CD5L can overcome resistance.

    • Christopher J. LaFargue
    • Paola Amero
    • Anil K. Sood
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miRNA-142-3p.

    • Jonathan Berrout
    • Eleni Kyriakopoulou
    • Zahra Timsah
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15