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Cell Death & Disease (1)

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VDAC2 loss elicits tumour destruction and inflammation for cancer therapy

VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.

Sujing Yuan
Renqiang Sun
Hongbo Chi
ResearchOpen Access19 Mar 2025
Nature

Volume: 640, P: 1062-1071
Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer

Analyses of causal gene regulatory networks have identified key checkpoints mediating the progressive differentiation of CD8⁺ cytotoxic T cells, findings that have implications for anticancer immunotherapies such as adoptive cell therapy and immune checkpoint blockade.

Peipei Zhou
Hao Shi
Hongbo Chi
ResearchOpen Access15 Nov 2023
Nature

Volume: 624, P: 154-163
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

Competition for glutamine between type-1 conventional dendritic cells and tumour cells has a central role in tuning the anti-tumour immune response and in immune evasion by cancer cells.

Chuansheng Guo
Zhiyuan You
Hongbo Chi
ResearchOpen Access05 Jul 2023
Nature

Volume: 620, P: 200-208
cBAF complex components and MYC cooperate early in CD8⁺ T cell fate

cBAF is a negative determinant of memory T cell fate and the manipulation of cBAF early in T cell differentiation can improve cancer immunotherapy.

Ao Guo
Hongling Huang
Douglas R. Green
Research22 Jun 2022
Nature

Volume: 607, P: 135-141
RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion

Yanni Xu
Liang Chu
Zongsuo Liang
ResearchOpen Access01 Jun 2017
Cell Death & Disease

Volume: 8, P: e2835