ALKBH8 is a tRNA methyltransferase, specifically modifying the wobble uridine (U34) in tRNAs. Here, the authors discover that ALKBH8 is a direct transcriptional target of β-catenin, and that mediates intestinal tumorigenesis through regulation of the translation of KRAS in a codon-dependent manner.
- Yu Qian
- Canlan Wu
- Xiangwei Gao
