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Advanced filters: Author: Sukdev Bag Clear advanced filters

  • Site-selective C–H functionalization still faces some challenges, such as the introduction and removal of an appropriate directing group. Here, the authors introduce a temporary directing group for selective meta-C–H functionalization of 2-arylbenzaldehydes via reversible imine formation.

    • Sukdev Bag
    • Sadhan Jana
    • Debabrata Maiti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Design strategies that possess both biological relevance and structural diversity may lead to compound collections that are enriched in diverse bioactivities. Now a diverse pseudo-natural product design principle has been established to efficiently explore biologically relevant chemical space. Through dearomatization reactions, a compound collection enriched in both structural and biological diversity was rapidly generated.

    • Sukdev Bag
    • Jie Liu
    • Herbert Waldmann
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 945-958