The authors show that extinction of fear conditioning lowers the threshold for synaptic potentiation in the lateral amygdala (LA), and fear renewal-inducing stimuli induce phosphorylation of AMPAR subunit GluA1 at serine 831 in LA. Infusion of a peptide competing with Ser831-phosphorylated GluA1 into the LA blocks this low-threshold potentiation and attenuates fear renewal.
- Sukwon Lee
- Beomjong Song
- Sukwoo Choi
