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Imaging deep within a scattering medium using collective accumulation of single-scattered waves

Using the collective accumulation of single-scattered waves, scientists manage to image deep within a scattering medium, achieving an imaging depth 11.5 times the scattering mean free path and a near-diffraction-limit resolution of 1.5 µm.

Sungsam Kang
Seungwon Jeong
Wonshik Choi
Research09 Mar 2015
Nature Photonics

Volume: 9, P: 253-258
Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin

The authors realize longitudinal deep-brain imaging through an intact mouse skull by constructing a high-speed reflection matrix microscope at 1.3 µm wavelength and developing a computational conjugate adaptive optics algorithm eliminating skull aberrations.

Yongwoo Kwon
Jin Hee Hong
Wonshik Choi
ResearchOpen Access06 Jan 2023
Nature Communications

Volume: 14, P: 1-9
Tracing multiple scattering trajectories for deep optical imaging in scattering media

Deep imaging in complex scattering media is hindered by multiple light scattering. Here, the authors proposed a method to trace multiple scattering trajectories in situ using a recorded reflection matrix and achieved enhanced imaging depth by converting these multiple scattering to signal waves.

Sungsam Kang
Yongwoo Kwon
Wonshik Choi
ResearchOpen Access28 Oct 2023
Nature Communications

Volume: 14, P: 1-12
High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering

Optical imaging deep in biological tissue is difficult due to multiple scattering and specimen induced aberrations of both the incident and reflected light. Here, Kang et al. develop an adaptive closed-loop algorithm to correct tissue aberrations in the presence of multiple scattering for deep tissue imaging.

Sungsam Kang
Pilsung Kang
Wonshik Choi
ResearchOpen Access18 Dec 2017
Nature Communications

Volume: 8, P: 1-10
Label-free neuroimaging in vivo using synchronous angular scanning microscopy with single-scattering accumulation algorithm

A major challenge of in vivo imaging is imaging deeper, including in turbid tissue. The authors report an adaptive optics based microscope that uses coherent single scattering signal to reduce sample-induced aberrations and enable fast deep-tissue imaging of in vivo larval zebrafish brain.

Moonseok Kim
Yonghyeon Jo
Wonshik Choi
ResearchOpen Access17 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Measuring the scattering tensor of a disordered nonlinear medium

Disordered media with their numerous scattering channels can be used as optical operators. Measurements of the scattering tensor of a second-harmonic medium extend this computing application to the nonlinear regime.

Jungho Moon
Ye-Chan Cho
Wonshik Choi
Research31 Jul 2023
Nature Physics

Volume: 19, P: 1709-1718
Focusing of light energy inside a scattering medium by controlling the time-gated multiple light scattering

The use of a time-gated reflection matrix of a scattering medium, in particular via using singular value decomposition and injecting light into the largest time-gated eigenchannel, can lead to a more than tenfold enhancement in light energy delivery in comparison with ordinary wave diffusion cases.

Seungwon Jeong
Ye-Ryoung Lee
Wonshik Choi
Research26 Mar 2018
Nature Photonics

Volume: 12, P: 277-283
Label-free characterization of ultra violet-radiation-induced changes in skin fibroblasts with Raman spectroscopy and quantitative phase microscopy

S. P. Singh
Sungsam Kang
Ishan Barman
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Mapping nanoscale topographic features in thick tissues with speckle diffraction tomography

New speckle diffraction tomography demonstrates high-resolution refractive index mapping of thick scattering tissue, red blood cell imaging behind turbid layers, and nanoscale features in the cornea using spatiotemporal gating and inverse-scattering model.

Sungsam Kang
Renjie Zhou
Zahid Yaqoob
ResearchOpen Access22 Aug 2023
Light: Science & Applications

Volume: 12, P: 1-9
Deep optical imaging within complex scattering media

Optical microscopy is limited to shallow in vivo imaging depths owing to the exponential extinction of single-scattered waves by multiple light scattering. In this Review, we survey methodologies for deep optical imaging that maintain microscopic resolution by making deterministic use of multiple-scattered waves.

Seokchan Yoon
Moonseok Kim
Wonshik Choi
Reviews20 Feb 2020
Nature Reviews Physics

Volume: 2, P: 141-158
High-throughput volumetric adaptive optical imaging using compressed time-reversal matrix

Compressed time-reversal matrix microscopy was developed for high-throughput volumetric adaptive optical imaging, enabling aberration-free visualization of myelinated axons in a mouse brain with high volumetric resolution.

Hojun Lee
Seokchan Yoon
Wonshik Choi
ResearchOpen Access14 Jan 2022
Light: Science & Applications

Volume: 11, P: 1-13
Observation of a non-equilibrium steady state of cold atoms in a moving optical lattice

Non-equilibrium dynamics of cold atoms have recently attracted attention revealing unconventional phenomena. The authors report here the experimental observation of a non-equilibrium steady state in a hybrid trap composed of a magneto-optical trap and a moving optical lattice.

Kyeong Ock Chong
Jung-Ryul Kim
Kyungwon An
ResearchOpen Access13 Jun 2018
Communications Physics

Volume: 1, P: 1-10
Optical imaging featuring both long working distance and high spatial resolution by correcting the aberration of a large aperture lens

Changsoon Choi
Kyung-Deok Song
Wonshik Choi
ResearchOpen Access15 Jun 2018
Scientific Reports

Volume: 8, P: 1-12

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