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Showing 1–7 of 7 results
Advanced filters: Author: Sunil J Advani Clear advanced filters

  • Tumors hijack cellular pathways to evade the effects of cancer therapy. Here, Advaniet al. show that DNA damage-induced phosphorylation of CRAF Serine 338 triggers DNA repair by recruiting CHK2, highlighting a role for CRAF independent from its canonical function as a kinase.

    • Sunil J. Advani
    • Maria Fernanda Camargo
    • David A. Cheresh
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Raf kinase activity is deregulated in cancers and is thought to promote tumor growth by inducing proliferation signaling through MEK/Erk. This report identifies a new role for c-Raf independent of MEK/Erk and relying on phosphorylation of Ser338. Phospho–C-Raf interacts with the mitotic kinases Aurora-A and Plk1, activating the latter to promote mitotic progression and increase cell division, and this pathway is a crucial mediator for the protumorigenic effect of c-Raf in vivo.

    • Ainhoa Mielgo
    • Laetitia Seguin
    • David A Cheresh
    Research
    Nature Medicine
    Volume: 17, P: 1641-1645

  • Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. Here the authors show that, in combination with radiotherapy, tumor-directed antibodies or peptides conjugated to MMAE promote anti-tumor immune responses, improving response to checkpoint inhibitors in preclinical cancer models.

    • Dina V. Hingorani
    • Michael M. Allevato
    • Sunil J. Advani
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.

    • RaeAnna Wilson
    • Cristina Espinosa-Diez
    • Sudarshan Anand
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Drugs that sensitize tumour cells to ionizing radiation are prized because they can overcome resistance to radiotherapy. Here, the authors show that anti-tubulin drugs conjugated to cetuximab or trastuzumab can radiosensitize EGFR- or HER2-expressing tumors by increasing DNA damage and cell death due to ionizing radiation.

    • Stephen R. Adams
    • Howard C. Yang
    • Sunil J. Advani
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Dexamethasone has been shown to have survival benefits for critically ill patients hospitalised with COVID-19 in the UK. Here, the authors estimated the number of lives that could be saved through a UK and global roll out of the drug and demonstrate that it is a cost-effective option.

    • Ricardo Águas
    • Adam Mahdi
    • Mesulame Namedre
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8