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Showing 1–7 of 7 results
Advanced filters: Author: Sunil R. Hingorani Clear advanced filters

  • Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. Here the authors show that, in combination with radiotherapy, tumor-directed antibodies or peptides conjugated to MMAE promote anti-tumor immune responses, improving response to checkpoint inhibitors in preclinical cancer models.

    • Dina V. Hingorani
    • Michael M. Allevato
    • Sunil J. Advani
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Isolation of individual cells from mixed populations is desirable for many biomedical applications. Here the authors use photoswitchable Pdots to allow 'optical painting', where cells of interest are marked based on their visual characteristics, and can then be isolated by fluorescence activated cell sorting.

    • Chun-Ting Kuo
    • Alison M. Thompson
    • Daniel T. Chiu
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • The incidence of pancreatic ductal adenocarcinoma (PDAC) has been increasing over the past few decades and survival rates for patients with this malignancy remain dismal. The authors of this Perspective discuss the challenges that have limited progress in the development of treatments for patients with PDAC and present novel approaches that could be leveraged to improve their outcomes.

    • Stephan B. Dreyer
    • Philip Beer
    • Andrew V. Biankin
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 439-456

  • Pancreatic ductal adenocarcinomas are characterized by a robust stromal reaction. This Review discusses how the evolution of the epithelium in pancreatic cancers is coordinated with a programme of stromal progression; this comprehensive picture of tumour development might, in turn, point to new therapeutic vulnerabilities.

    • Sunil R. Hingorani
    Reviews
    Nature Reviews Cancer
    Volume: 23, P: 57-77

  • This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment.

    • Erik Sahai
    • Igor Astsaturov
    • Zena Werb
    ReviewsOpen Access
    Nature Reviews Cancer
    Volume: 20, P: 174-186