Nature Search

Collective total synthesis of C4-oxygenated securinine-type alkaloids via stereocontrolled diversifications on the piperidine core

A general synthetic solution toward high-oxidation state securinega alkaloids could be useful for systematic biological studies. Here, the authors report a divergent synthesis of C4-oxygenated securinega alkaloids via stereocontrolled diversifications on the piperidine core.

Sangbin Park
Gyumin Kang
Sunkyu Han
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-8
Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion

The Ssu72 phosphatase is required to prevent premature separation of sister chromatids during interphase. Kim et al.show that this signal is terminated at early mitosis by Aurora B, which phosphorylates Ssu72 and promotes its ubiquitin-dependent degradation.

Hyun-Soo Kim
Se-Hyuk Kim
Chang-Woo Lee
Research23 Oct 2013
Nature Communications

Volume: 4, P: 1-14
Unidirectional scattering with spatial homogeneity using correlated photonic time disorder

Photonic systems can exploit time as a degree of freedom analogous to space, eliminating the need for spatial patterning to achieve functionality. A Green’s function approach allows the design of disordered time scatterers with desired properties.

Jungmin Kim
Dayeong Lee
Namkyoo Park
ResearchOpen Access20 Feb 2023
Nature Physics

Volume: 19, P: 726-732
Low-dimensional gap plasmons for enhanced light-graphene interactions

Yunjung Kim
Sunkyu Yu
Namkyoo Park
ResearchOpen Access27 Feb 2017
Scientific Reports

Volume: 7, P: 1-7
Author Correction: Long-range-interacting topological photonic lattices breaking channel-bandwidth limit

Gyunghun Kim
Joseph Suh
Sunkyu Yu
Amendments and CorrectionsOpen Access04 Jan 2025
Light: Science & Applications

Volume: 14, P: 1-2
Crowdsourced mapping of unexplored target space of kinase inhibitors

The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts.

Anna Cichońska
Balaguru Ravikumar
Tero Aittokallio
ResearchOpen Access03 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Michael P. Menden
Dennis Wang
Julio Saez-Rodriguez
ResearchOpen Access17 Jun 2019
Nature Communications

Volume: 10, P: 1-17
Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Small molecules are identified that inhibit the ubiquitin-specific protease USP7 with high affinity and specificity as explained by co-crystal structures, and are shown to reduce tumour growth in mice.

Andrew P. Turnbull
Stephanos Ioannidis
David Komander
Research18 Oct 2017
Nature

Volume: 550, P: 481-486
Golgin45-Syntaxin5 Interaction Contributes to Structural Integrity of the Golgi Stack

Neeraj Tiwari
Morven Graham
Intaek Lee
ResearchOpen Access28 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
Cyclin C is a haploinsufficient tumour suppressor

Through gene knockout experiments, Sicinski and colleagues reveal a role for cyclin C as a haploinsufficient tumour suppressor in T-cell acute lymphoblastic leukaemia, acting through phosphorylation of intracellular Notch1, mediating its degradation.

Na Li
Anne Fassl
Piotr Sicinski
Research26 Oct 2014
Nature Cell Biology

Volume: 16, P: 1080-1091
Long-range-interacting topological photonic lattices breaking channel-bandwidth limit

Topological lattices with long-range interactions enable increased Chern numbers and wide bandgaps, achieving defect-robust multichannel processing.

Gyunghun Kim
Joseph Suh
Sunkyu Yu
ResearchOpen Access02 Sept 2024
Light: Science & Applications

Volume: 13, P: 1-9
A large-scale reaction dataset of mechanistic pathways of organic reactions

Shuan Chen
Ramil Babazade
Yousung Jung
ResearchOpen Access10 Aug 2024
Scientific Data

Volume: 11, P: 1-9
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

Tai Young Kim
Sangeun Jeon
C. Justin Lee
ResearchOpen Access25 May 2021
Experimental & Molecular Medicine

Volume: 53, P: 956-972
Engineered disorder in photonics

In photonics, the introduction of order and disorder has traditionally been treated separately. However, recent developments in nanofabrication and design strategies have enabled the use of materials that lie between the extremes of order and disorder that can yield innovative optical phenomena. This Review surveys the basics and recent achievements of engineered disorder in photonics.

Sunkyu Yu
Cheng-Wei Qiu
Namkyoo Park
Reviews09 Dec 2020
Nature Reviews Materials

Volume: 6, P: 226-243
Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

A screen for compounds that may inhibit the growth of hematological malignancies reveals the specific dependence of some mantle cell lymphoma (MCL) cell lines on canonical or alternative NF-κB signaling. As also seen in patients, genetic alterations affecting alternative NF-κB signaling confer insensibility to ibrutinib, a compound that was recently approved for MCL treatment. This alternative signaling pathway underscores the need to tailor treatments to the specific driving pathways in each patient group.

Rami Rahal
Mareike Frick
Frank Stegmeier
Research22 Dec 2013
Nature Medicine

Volume: 20, P: 87-92
Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model

Yun Jeong Lee
Sooyoung Yoo
Jae Hyun Kim
ResearchOpen Access16 Jul 2021
Scientific Reports

Volume: 11, P: 1-8
Progressive structural changes of Avicel, bleached softwood and bacterial cellulose during enzymatic hydrolysis

Kabindra Kafle
Heenae Shin
Seong H. Kim
ResearchOpen Access14 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
Validating cancer drug targets

John D. Benson
Ying-Nan P. Chen
Christoph Lengauer
Reviews24 May 2006
Nature

Volume: 441, P: 451-456
Bidirectional meta-Kronecker factored optimizer and Hausdorff distance loss for few-shot medical image segmentation

Yeongjoon Kim
Donggoo Kang
Joonki Paik
ResearchOpen Access19 May 2023
Scientific Reports

Volume: 13, P: 1-18
Building a PubMed knowledge graph

Jian Xu
Sunkyu Kim
Ying Ding
ResearchOpen Access26 Jun 2020
Scientific Data

Volume: 7, P: 1-15

Search

Collective total synthesis of C4-oxygenated securinine-type alkaloids via stereocontrolled diversifications on the piperidine core

Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion

Unidirectional scattering with spatial homogeneity using correlated photonic time disorder

Low-dimensional gap plasmons for enhanced light-graphene interactions

Author Correction: Long-range-interacting topological photonic lattices breaking channel-bandwidth limit

Crowdsourced mapping of unexplored target space of kinase inhibitors

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Golgin45-Syntaxin5 Interaction Contributes to Structural Integrity of the Golgi Stack

Cyclin C is a haploinsufficient tumour suppressor

Long-range-interacting topological photonic lattices breaking channel-bandwidth limit

A large-scale reaction dataset of mechanistic pathways of organic reactions

Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

Engineered disorder in photonics

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model

Progressive structural changes of Avicel, bleached softwood and bacterial cellulose during enzymatic hydrolysis

Validating cancer drug targets

Bidirectional meta-Kronecker factored optimizer and Hausdorff distance loss for few-shot medical image segmentation

Building a PubMed knowledge graph

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