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Showing 1–2 of 2 results
Advanced filters: Author: Surl-Hee Ahn Clear advanced filters

  • The opening mechanism of the SARS-CoV-2 spike protein has been studied by integrating computational and experimental data. Combining weighted ensemble molecular dynamics simulations, biolayer interferometry and ManifoldEM analysis of cryo-EM data revealed that the glycan at N343 plays a gating role in the opening mechanism of the SARS-CoV-2 spike protein.

    • Terra Sztain
    • Surl-Hee Ahn
    • Rommie E. Amaro
    Research
    Nature Chemistry
    Volume: 13, P: 963-968

  • The evolutionarily conserved SARS-CoV-2 spike’s S2 subunit provides the foundation for its usage as an immunogen in vaccines. Here, the authors use a simulation-driven approach to design S2-only immunogens stabilized in the closed prefusion conformation.

    • Xandra Nuqui
    • Lorenzo Casalino
    • Rommie E. Amaro
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15