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The hidden costs of flexible fertility

Urgent public debate is needed over a European proposal to regulate environmental levels of the active ingredient in birth-control pills, say Richard Owen and Susan Jobling.

Richard Owen
Susan Jobling
Comments & Opinion23 May 2012
Nature

Volume: 485, P: 441
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
^hInGeTox: a human-based in vitro platform to evaluate lentivirus/host interactions that contribute to genotoxicity

Saqlain Suleman
Sharmin Alhaque
Michael Themis
ResearchOpen Access15 Jul 2025
Gene Therapy

P: 1-16
Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

Coen M. Adema
LaDeana W. Hillier
Richard K. Wilson
ResearchOpen Access16 May 2017
Nature Communications

Volume: 8, P: 1-12
Correction: Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Coen M. Adema
LaDeana W. Hillier
Richard K. Wilson
Amendments and CorrectionsOpen Access23 Aug 2017
Nature Communications

Volume: 8, P: 1
Removal of ecotoxicity of 17α-ethinylestradiol using TAML/peroxide water treatment

Matthew R. Mills
Karla Arias-Salazar
Terrence J. Collins
ResearchOpen Access12 Jun 2015
Scientific Reports

Volume: 5, P: 1-10
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang
Dane Cheasley
Kylie L. Gorringe
Research28 Jul 2020
Modern Pathology

Volume: 34, P: 194-206
Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Genome-wide association studies have identified regions which confer risk of high-grade serous epithelial ovarian cancer. Here the authors use expression quantitative train locus analysis to identify candidate genes and functionally characterise them, identifying a role for HOXD9 in ovarian cancer.

Kate Lawrenson
Qiyuan Li
Matthew L. Freedman
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-14
Periodic reanalysis of whole-genome sequencing data enhances the diagnostic advantage over standard clinical genetic testing

Gregory Costain
Rebekah Jobling
Christian R. Marshall
Research16 Feb 2018
European Journal of Human Genetics

Volume: 26, P: 740-744
Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot

Miriam S. Reuter
Rebekah Jobling
Anne S. Bassett
ResearchOpen Access20 Sept 2018
Genetics in Medicine

Volume: 21, P: 1001-1007
Molecular evidence for absence of Y-linkage of the Hairy Ears trait

Andrew C Lee
Angamuthu Kamalam
Mark A Jobling
Research15 Sept 2004
European Journal of Human Genetics

Volume: 12, P: 1077-1079
HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival

Saqlain Suleman
Annette Payne
Michael Themis
ResearchOpen Access05 May 2022
Gene Therapy

Volume: 29, P: 720-729
Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell

Alice Baynes
Gemma Montagut Pino
Edwin J. Routledge
ResearchOpen Access11 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test

Anath C Lionel
Gregory Costain
Christian R Marshall
ResearchOpen Access03 Aug 2017
Genetics in Medicine

Volume: 20, P: 435-443

Search

The hidden costs of flexible fertility

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

^hInGeTox: a human-based in vitro platform to evaluate lentivirus/host interactions that contribute to genotoxicity

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Correction: Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Removal of ecotoxicity of 17α-ethinylestradiol using TAML/peroxide water treatment

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Periodic reanalysis of whole-genome sequencing data enhances the diagnostic advantage over standard clinical genetic testing

Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot

Molecular evidence for absence of Y-linkage of the Hairy Ears trait

HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival

Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell

Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test

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