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Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder

The NRF2 transcription factor regulates the response to stress in mammalian cells. Here, the authors show that activating mutations in NRF2, commonly found in cancer cells, are found in four patients with a multisystem disorder characterized by immunodeficiency and neurological symptoms.

Peter Huppke
Susann Weissbach
Jutta Gärtner
ResearchOpen Access10 Oct 2017
Nature Communications

Volume: 8, P: 1-10
Community and single cell analyses reveal complex predatory interactions between bacteria in high diversity systems

Studying the role of predator–prey interactions in food-web stability and species coexistence in the environment is arduous. Here, Cohen et al. use a combination of community and single-cell analyses to show that bacterial predators can regulate prey populations in the species-rich environments of wastewater treatment plants.

Yossi Cohen
Zohar Pasternak
Edouard Jurkevitch
ResearchOpen Access16 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine

Due to a microbiota-dependent increase in intestinal permeability with age, the gut metabolite N⁶-carboxymethyllysine accumulates in the microglia of mouse and human brains. As a result, microglia display increased oxidative stress and mitochondrial dysfunction.

Omar Mossad
Bérénice Batut
Thomas Blank
Research03 Mar 2022
Nature Neuroscience

Volume: 25, P: 295-305
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

Inhibition of YBX1, a downstream target of the Janus kinase JAK2, sensitizes myeloproliferative neoplasm cells to JAK and could provide a means to eradicate such cells in human haematopoietic cancers.

Ashok Kumar Jayavelu
Tina M. Schnöder
Florian H. Heidel
Research25 Nov 2020
Nature

Volume: 588, P: 157-163
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST⁺ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY⁺ hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.

Syed Ahsan Raza
Anne Albrecht
Oliver Stork
ResearchOpen Access04 Aug 2017
Nature Communications

Volume: 8, P: 1-15
Adipokines in bone disease

The influence of adipokines on the pathogenesis and progression of rheumatic diseases is increasingly appreciated. In particular, these factors have complex roles not only in inflammation, but in tissue remodelling. This Review focuses on the effects of distinct adipokines on bone cells and bone remodelling, and discusses whether these mechanisms could be targeted therapeutically.

Elena Neumann
Susann Junker
Ulf Müller-Ladner
Reviews15 Apr 2016
Nature Reviews Rheumatology

Volume: 12, P: 296-302
Potential of microbiome-based solutions for agrifood systems

Few microbiome-based solutions for agricultural productivity, food processing and human nutrition have been successfully commercialized. A systems-based approach that considers the ecology of microbial communities may help finetune extant tools to increase their reliability while promoting innovation and greater adoption.

Stephanie D. Jurburg
Nico Eisenhauer
Brajesh K. Singh
Comments & Opinion10 Aug 2022
Nature Food

Volume: 3, P: 557-560
Bacterial mock communities as standards for reproducible cytometric microbiome analysis

Flow cytometry is used to track dynamics in microbial communities and link these changes with ecological parameters. This protocol describes how to prepare a fixed microbial cytometric mock community to standardize results over large-scale studies.

Nicolas Cichocki
Thomas Hübschmann
Susann Müller
Protocols07 Aug 2020
Nature Protocols

Volume: 15, P: 2788-2812
Isolation of intact RNA from cytometrically sorted Saccharomyces cerevisiae for the analysis of intrapopulation diversity of gene expression

Jeannette Achilles
Frank Stahl
Susann Müller
Protocols13 Sept 2007
Nature Protocols

Volume: 2, P: 2203-2211
Structural basis of oligomerization in the stalk region of dynamin-like MxA

Dynamin is a protein that catalyses the scission of clathrin-coated pits at the plasma membrane. The mechanisms of dynamin-catalysed scission remain poorly understood. Here, the structure of the stalk region of human MxA, a dynamin-like protein, is presented. A structural model of MxA oligomerization and stimulated GTP hydrolysis is put forward that has functional implications for all members of the dynamin family.

Song Gao
Alexander von der Malsburg
Oliver Daumke
Research28 Apr 2010
Nature

Volume: 465, P: 502-506
Cytometric fingerprinting for analyzing microbial intracommunity structure variation and identifying subcommunity function

Christin Koch
Susanne Günther
Susann Müller
Protocols03 Jan 2013
Nature Protocols

Volume: 8, P: 190-202
Huntingtin CAG repeat size variations below the Huntington’s disease threshold: associations with depression, anxiety and basal ganglia structure

Magdalena Vater
Nicolas Rost
Elisabeth B. Binder
ResearchOpen Access21 Nov 2024
European Journal of Human Genetics

Volume: 33, P: 624-632
Natural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data

Susann Mönchgesang
Nadine Strehmel
Dierk Scheel
ResearchOpen Access01 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR^low/neg monocytes in lower-risk myelodysplastic neoplasms

Susann Winter
Marie Schneider
Shahram Kordasti
ResearchOpen Access17 Apr 2024
Leukemia

Volume: 38, P: 1427-1431
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

Search

Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder

Community and single cell analyses reveal complex predatory interactions between bacteria in high diversity systems

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Adipokines in bone disease

Potential of microbiome-based solutions for agrifood systems

Bacterial mock communities as standards for reproducible cytometric microbiome analysis

Isolation of intact RNA from cytometrically sorted Saccharomyces cerevisiae for the analysis of intrapopulation diversity of gene expression

Structural basis of oligomerization in the stalk region of dynamin-like MxA

Cytometric fingerprinting for analyzing microbial intracommunity structure variation and identifying subcommunity function

Huntingtin CAG repeat size variations below the Huntington’s disease threshold: associations with depression, anxiety and basal ganglia structure

Natural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data

Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR^low/neg monocytes in lower-risk myelodysplastic neoplasms

AI is a viable alternative to high throughput screening: a 318-target study

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

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