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Advanced filters: Author: Sushant Saluja Clear advanced filters

Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Genetic mechanisms of blood pressure regulation remain poorly defined. Here, the authors perform a kidney multi-omics study to identify 399 kidney effector genes, 11 miRNAs and 97 proteins for blood pressure and hypertension.

Xiaoguang Xu
Chachrit Khunsriraksakul
Maciej Tomaszewski
ResearchOpen Access19 Mar 2024
Nature Communications

Volume: 15, P: 1-29
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney

Gene expression, alternative splicing and DNA methylation profiles from human kidney samples provide insights into the effects of common variants influencing blood pressure. Mendelian randomization uncovers the effects of blood pressure on renal outcomes.

James M. Eales
Xiao Jiang
Maciej Tomaszewski
Research06 May 2021
Nature Genetics

Volume: 53, P: 630-637

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Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney

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