In osteoporosis, bone marrow adipocytes (BMAds) accumulate, but their functions are not well understood. Here, Lin et al. show that BMAds promote senescence in neighbouring cells by releasing excess fatty acids, then develop a BMAd targeting nanoparticle to interfere with BMAd lipid metabolism as a strategy to treat osteoporosis.
- Wenzheng Lin
- Suyu Gu
- Hao Chen
