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Showing 1–9 of 9 results
Advanced filters: Author: Suzanne Elizabeth Eldridge Clear advanced filters

  • Evidence synthesized from 252 large-herbivore exclusion studies suggests that herbivore-induced change in dominance, independent of site productivity or precipitation, best predicts herbivore effects on biodiversity in grassland and savannah sites.

    • Sally E. Koerner
    • Melinda D. Smith
    • Tamara Jane Zelikova
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 1925-1932

  • Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

    • Panu Somervuo
    • Tomas Roslin
    • Otso Ovaskainen
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 9, P: 1585-1598

  • Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

    • Andrew V. Biankin
    • Nicola Waddell
    • Sean M. Grimmond
    Research
    Nature
    Volume: 491, P: 399-405

  • A whole-genome sequencing analysis of 100 pancreatic ductal adenocarcinomas has discovered known and newly identified genetic drivers of pancreatic cancer; these genetic alterations can be classified into four subtypes, which raises the possibility of improved targeting of clinical treatments.

    • Nicola Waddell
    • Marina Pajic
    • Sean M. Grimmond
    Research
    Nature
    Volume: 518, P: 495-501

  • The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.

    • Aldo Scarpa
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 543, P: 65-71

  • The authors identify copy number signatures from shallow whole-genome sequencing of high-grade serous ovarian cancer (HGSOC) cases. HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in genomic aberration.

    • Geoff Macintyre
    • Teodora E. Goranova
    • James D. Brenton
    Research
    Nature Genetics
    Volume: 50, P: 1262-1270

  • An integrated genomic analysis of 456 human pancreatic ductal adenocarcinomas identifies four subtypes defined by transcriptional expression profiles and show that these are associated with distinct histopathological characteristics and differential prognosis.

    • Peter Bailey
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 531, P: 47-52

  • An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with KrasG12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

    • Pedro A. Pérez-Mancera
    • Alistair G. Rust
    • David A. Tuveson
    Research
    Nature
    Volume: 486, P: 266-270