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Showing 1–3 of 3 results
Advanced filters: Author: Suzanne J Randle Clear advanced filters

  • This study reports on an AI-powered autonomous experimentation platform that overcomes data scarcity in electronic materials discovery by using an AI advisor for real-time progress monitoring, data analysis and interactive human–AI collaboration. Applied to mixed ion–electron conducting polymers, it rapidly optimized performance in 64 experimental trials, revealing morphology–property relationships and an unreported polymer polymorph.

    • Yahao Dai
    • Henry Chan
    • Jie Xu
    Research
    Nature Chemical Engineering
    Volume: 2, P: 760-770

  • Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neutrophil differentiation.

    • David B. Chou
    • Brooke A. Furlong
    • Donald E. Ingber
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Mutations in the gene encoding the F-box domain–containing protein Fbxo7 are genetically associated to an autosomal recessive form of early-onset Parkinson's disease of similar severity to those caused by Parkinson's disease–linked mutations in the genes for the mitochondrial kinase PINK1 or the E3 ubiquitin ligase Parkin. Burchell et al. show that Fbxo7 acts in a common cellular and molecular pathway with Parkin and PINK1 in autophagic clearance of mitochondria in response to mitochondrial depolarization and damage.

    • Victoria S Burchell
    • David E Nelson
    • Helene Plun-Favreau
    Research
    Nature Neuroscience
    Volume: 16, P: 1257-1265