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Showing 1–4 of 4 results
Advanced filters: Author: Suzanne Mac Rae Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Genome-wide association analysis of an improved telomere length score, calculated from quantitative PCR and whole-genome sequencing measurements in 462,666 individuals in the UK Biobank, identifies novel genes and variants underlying this trait.

    • Oliver S. Burren
    • Ryan S. Dhindsa
    • Slavé Petrovski
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1832-1840

  • The prognosis for patients with advanced melanoma and CNS metastases is poor. Hodi et al. report the case of a 63-year-old female who was diagnosed with metastatic melanoma from an unknown primary tumor. The authors discuss the use of the human monoclonal antibody against CTLA-4, ipilimumab, in patients with metastatic melanoma.

    • F Stephen Hodi
    • Darryl A Oble
    • Martin Mihm
    Reviews
    Nature Clinical Practice Oncology
    Volume: 5, P: 557-561