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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury

Zambusi, Novoselc et al. show that granulin-mediated clearance of cytoplasmic TDP-43⁺ condensates and lipid droplets in injury-activated microglia is required for their return to the homeostatic state and successful brain regeneration.

Alessandro Zambusi
Klara Tereza Novoselc
Jovica Ninkovic
Research24 Nov 2022
Nature Neuroscience

Volume: 25, P: 1608-1625

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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury

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