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Showing 1–6 of 6 results
Advanced filters: Author: Sven Reischauer Clear advanced filters

  • Zebrafish can regenerate damaged myocardial tissue but it is unclear how this is regulated. Here, the authors show that two TGF-β family members, Mstnb and Inhbaa, have opposite effects in regeneration, with mstnb overexpression or inhbaa loss-of-function causing cardiac scarring after injury.

    • Deepika Dogra
    • Suchit Ahuja
    • Sven Reischauer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functionality of this MYL4mutation in zebrafish cardiac function and recapitulate disease-related phenotypes.

    • Nathan Orr
    • Rima Arnaout
    • Michael H. Gollob
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • The zebrafish cloche gene is required for the formation of most endothelial and haematopoietic cells, however, it has been difficult to isolate; this study reveals that cloche encodes a PAS-domain-containing bHLH transcription factor, and a mammalian orthologue can partially rescue cloche mutants, indicating a possible conserved role in mammals.

    • Sven Reischauer
    • Oliver A. Stone
    • Didier Y. R. Stainier
    Research
    Nature
    Volume: 535, P: 294-298

  • Cell fusion regulates several physiological events, for example, fusion of myoblasts in skeletal muscle formation, but it is unclear if this process occurs in the heart. Here, the authors use transgenic reporters in zebrafish to show transient cardiomyocyte fusion, modulating cardiac development and function.

    • Suphansa Sawamiphak
    • Zacharias Kontarakis
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • A series of technical and analytical improvements to light sheet microscopy is described, permitting dynamic imaging of the beating zebrafish heart at cellular resolution.

    • Michaela Mickoleit
    • Benjamin Schmid
    • Jan Huisken
    Research
    Nature Methods
    Volume: 11, P: 919-922