Nature Search

NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake

Genome-wide CRISPR/Cas9 screening identifies the N-terminal acetyltransferase NAA60 to facilitate cis- and carboplatin drug sensitivity, most likely by neutralizing Nt acetylation of the LRRC8A/D VRAC subunits regulating substrate permeability.

Carmen Alexandra Widmer
Anna Moyseos
Sven Rottenberg
ResearchOpen Access06 Oct 2025
Communications Biology

Volume: 8, P: 1-18
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

53BP1 is a key player in non-homologous end joining (NHEJ). Here the authors reveal an important role for the multifunctional homodimeric protein hub dynein light chain 1 (DYNLL1) in increasing the efficacy of 53BP1-mediated repair of DNA double-strand breaks (DSBs) by NHEJ.

Jordan R. Becker
Raquel Cuella-Martin
J. Ross Chapman
ResearchOpen Access17 Dec 2018
Nature Communications

Volume: 9, P: 1-12
REV7 counteracts DNA double-strand break resection and affects PARP inhibition

Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of homologous recombination; REV7 dictates pathway choice in BRCA1-deficient cells and during immunoglobulin class switching.

Guotai Xu
J. Ross Chapman
Sven Rottenberg
Research23 Mar 2015
Nature

Volume: 521, P: 541-544
BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

Mouse tumor organoids are characterized as a model to study tumor biology and drug resistance.

Alexandra A Duarte
Ewa Gogola
Sven Rottenberg
Research11 Dec 2017
Nature Methods

Volume: 15, P: 134-140
H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Histone H2AX has a known role in DNA damage repair but interestingly, its loss is associated with resistance to poly(ADP-ribose) polymerase (PARP) inhibition in BRCA-deficient tumours. Here, the authors identify a role of γH2AX in the degradation of replication forks and demonstrate that H2AX loss drives PARP inhibitor resistance via increased stressed fork stability in BRCA-deficient tumours.

Diego Dibitetto
Martin Liptay
Sven Rottenberg
ResearchOpen Access24 May 2024
Nature Communications

Volume: 15, P: 1-14
Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites

Maurizio and Masid et al. identify common host metabolic pathways essential for Plasmodium falciparum and Theileria parasites, revealing potential for developing shared broad-spectrum antiparasitic therapies to more effectively combat these debilitating infections.

Marina Maurizio
Maria Masid
Philipp Olias
ResearchOpen Access21 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells

Arnab Ray Chaudhuri
Elsa Callen
André Nussenzweig
Amendments and Corrections28 Sept 2016
Nature

Volume: 539, P: 456
Chrysalis: decoding tissue compartments in spatial transcriptomics with archetypal analysis

Chrysalis, a machine learning-based framework accurately infers cellular niches and underlying gene expression programs in the tissue from spatial transcriptomics data. It demonstrates robust performance on a diverse set of tissues and platforms.

Demeter Túrós
Jelica Vasiljevic
Alberto Valdeolivas
ResearchOpen Access16 Nov 2024
Communications Biology

Volume: 7, P: 1-15
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Truncation of exon 18 of FGFR2 (FGFR2^ΔE18) is a potent driver mutation in mice and humans, and FGFR-targeted therapy should be considered for patients with cancer expressing stable FGFR2^ΔE18 variants.

Daniel Zingg
Jinhyuk Bhin
Jos Jonkers
ResearchOpen Access10 Aug 2022
Nature

Volume: 608, P: 609-617
Replication fork stability confers chemoresistance in BRCA-deficient cells

Protection of nascent DNA from degradation provides a mechanism that can promote synthetic viability and drug resistance in Brca-deficient cells without restoring homologous recombination at double-strand breaks.

Arnab Ray Chaudhuri
Elsa Callen
André Nussenzweig
Research20 Jul 2016
Nature

Volume: 535, P: 382-387
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

Anthracycline-based drugs can kill cancer cells by inhibiting topoisomerase II and promoting DNA double-strand breaks. Pang et al. show that anthracyclines also induce eviction of histones from open chromatin regions and, in doing so, modulate DNA repair and apoptosis in human cancer cells.

Baoxu Pang
Xiaohang Qiao
Jacques Neefjes
ResearchOpen Access28 May 2013
Nature Communications

Volume: 4, P: 1-13
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

Mutations in BRCA1 and BRCA2 render a cancer cell hypersensitive to PARP inhibitors but they can acquire resistance and relapse. Here the authors find that PARP inhibition leads to replication fork instability, cytokinesis failure and cell death, aiding our understanding of how inhibition leads to cytotoxic outcomes.

Pepijn M. Schoonen
Francien Talens
Marcel A. T. M. van Vugt
ResearchOpen Access17 Jul 2017
Nature Communications

Volume: 8, P: 1-13
Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Daniel Zingg
Jinhyuk Bhin
Jos Jonkers
Amendments and CorrectionsOpen Access01 Sept 2022
Nature

Volume: 609, P: E13
53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

The specificity of 53BP1 and its co-factors for particular DNA substrates during non-homologous end joining (NHEJ) derives from REV7–shieldin, a four-subunit DNA-binding complex that is required for REV7-dependent NHEJ but not for REV7-dependent DNA interstrand cross-link repair.

Hind Ghezraoui
Catarina Oliveira
J. Ross Chapman
Research25 Jul 2018
Nature

Volume: 560, P: 122-127
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer

Marine Inglebert
Martina Dettwiler
Sven Rottenberg
ResearchOpen Access27 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
The shieldin complex mediates 53BP1-dependent DNA repair

The 53BP1 effector complex shieldin is involved in non-homologous end-joining and immunoglobulin class switching, and acts to protect DNA ends to facilitate the repair of DNA by 53BP1.

Sylvie M. Noordermeer
Salomé Adam
Daniel Durocher
Research18 Jul 2018
Nature

Volume: 560, P: 117-121
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2 contributes to PARPi resistance in BRCA2-deficient tumours.

Beatrice Rondinelli
Ewa Gogola
Alan D. D’Andrea
Research16 Oct 2017
Nature Cell Biology

Volume: 19, P: 1371-1378
Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1)

S. Lot Aronson
Cédric Walker
Kerstin Hahn
Research12 Jun 2024
British Journal of Cancer

Volume: 131, P: 565-576
Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics

Alberto Valdeolivas
Bettina Amberg
Kerstin Hahn
ResearchOpen Access10 Jan 2024
npj Precision Oncology

Volume: 8, P: 1-16
The rediscovery of platinum-based cancer therapy

Platinum chemotherapy agents remain among the most widely used anticancer drugs, but there is still room to maximize their efficacy. This Review discusses newer findings related to sensitivity and resistance to these drugs as well as recent advances in platinum drug development.

Sven Rottenberg
Carmen Disler
Paola Perego
Reviews30 Oct 2020
Nature Reviews Cancer

Volume: 21, P: 37-50
PatchSorter: a high throughput deep learning digital pathology tool for object labeling

Cédric Walker
Tasneem Talawalla
Andrew Janowczyk
ResearchOpen Access20 Jun 2024
npj Digital Medicine

Volume: 7, P: 1-7

Search

NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites

Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells

Chrysalis: decoding tissue compartments in spatial transcriptomics with archetypal analysis

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Replication fork stability confers chemoresistance in BRCA-deficient cells

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer

The shieldin complex mediates 53BP1-dependent DNA repair

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1)

Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics

The rediscovery of platinum-based cancer therapy

PatchSorter: a high throughput deep learning digital pathology tool for object labeling

Search

Quick links

Search

Filter By:

Search

Quick links