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Showing 1–4 of 4 results
Advanced filters: Author: Svetlana Shulga-Morskaya Clear advanced filters

  • Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.

    • Megha Subramanian
    • James McIninch
    • Vasant Jadhav
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • A subset of chemically-modified siRNAs conjugated to trivalent GalNAc may fail during nonclinical development due to rat hepatotoxicity. Here, the authors show that hepatotoxicity may be accounted for by microRNA-like off-target effects of siRNA and can be mitigated by a thermally destabilizing modification in the siRNA seed region.

    • Maja M. Janas
    • Mark K. Schlegel
    • Vasant Jadhav
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • siRNA is used to silence expression of a specific gene and, if modified by a triphosphate at the 5′ end, will also activate the helicase Rig-I, leading to interferon production. Poeck et al. now combine both of these activities in a single siRNA to kill melanoma cells by crippling a crucial tumor cell survival pathway and triggering an interferon-dependent antitumor immune response (pages 1152–1153).

    • Hendrik Poeck
    • Robert Besch
    • Gunther Hartmann
    Research
    Nature Medicine
    Volume: 14, P: 1256-1263

  • Gene silencing by siRNAs in vivo is reversed using sequence-specific high-affinity oligonucleotides.

    • Ivan Zlatev
    • Adam Castoreno
    • Vasant Jadhav
    Research
    Nature Biotechnology
    Volume: 36, P: 509-511