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Showing 1–2 of 2 results
Advanced filters: Author: Syam Sundar Neti Clear advanced filters

  • LipCo biosynthesis in humans depends exclusively on a de novo pathway involving LIPT2, LIAS, and LIPT1. In this work authors present structures of LIAS captured in multiple catalytic states, revealing critical conformational changes associated with the reaction. The structures of the LIAS–Hpro complex define molecular interactions essential for complex formation. These structures enabled the mapping of amino acid changes associated with non-ketotic hyperglycemia.

    • Olga A. Esakova
    • Douglas M. Warui
    • Squire J. Booker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Enzymes with identical sequences of amino acids can display varying activities when encoded with mRNA with different properties, but why this is the case has been a mystery. Now, it has been shown that synonymous mutations in mRNA alter the partitioning of proteins into long-lived soluble misfolded states with varying activities.

    • Yang Jiang
    • Syam Sundar Neti
    • Edward P. O’Brien
    Research
    Nature Chemistry
    Volume: 15, P: 308-318