Here, using ribosomal profiling, the authors characterize the translatome of HIV-1 revealing tens of alternative open reading frames (ARF) that encode conserved viral antigens and show that ARF-derived peptides elicit potent HIV-specific poly-functional immune responses mediated by both CD4+ and CD8+ T cells.
- Lisa Bertrand
- Annika Nelde
- Arnaud Moris
