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Activation of a FOXO3-induced cell cycle arrest regulates ferroptosis

Huanjie Huang
Matthias van Sligtenhorst
Boudewijn M. T. Burgering
ResearchOpen Access16 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-15
Direct detection of 8-oxo-dG using nanopore sequencing

Oxidative DNA damage is linked to cancer and aging, but its genomic effects remain hard to map. Here, authors develop a nanopore-based method using synthetic DNA and deep learning to detect 8- oxo-dG, revealing its distribution and interplay with DNA methylation.

Marc Pagès-Gallego
Daan M. K. van Soest
Jeroen de Ridder
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-15
Mitochondrial H₂O₂ release does not directly cause damage to chromosomal DNA

Nuclear DNA damage downstream of mitochondrial ROS is often cited to contribute to cancer initiation and aging. However, here the authors show that although H₂O₂ induces DNA mutations when produced near DNA, it does not when released by mitochondria.

Daan M. K. van Soest
Paulien E. Polderman
Tobias B. Dansen
ResearchOpen Access28 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

Tobias B Dansen
Lydia M M Smits
Boudewijn M T Burgering
Research02 Aug 2009
Nature Chemical Biology

Volume: 5, P: 664-672
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Geert J. P. L. Kops
Tobias B. Dansen
Boudewijn M. T. Burgering
Research19 Sept 2002
Nature

Volume: 419, P: 316-321
Apoptosis and cancer: the genesis of a research field

Ever since its discovery, apoptosis has been inextricably linked with cancer. This Timeline article seeks to provide insights into the key discoveries in the field and therapeutic applications based on apoptotic strategies.

Thomas G. Cotter
Reviews01 Jul 2009
Nature Reviews Cancer

Volume: 9, P: 501-507
Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak

D Neise
V Graupner
F Essmann
Research03 Sept 2007
Oncogene

Volume: 27, P: 1387-1396
FOXO1 is a TXN- and p300-dependent sensor and effector of oxidative stress in diffuse large B-cell lymphomas characterized by increased oxidative metabolism

T Sewastianik
M Szydlowski
P Juszczynski
Research02 May 2016
Oncogene

Volume: 35, P: 5989-6000
Interplay between metabolic identities in the intestinal crypt supports stem cell function

The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt.

Maria J. Rodríguez-Colman
Matthias Schewe
Boudewijn M. T. Burgering
Research08 Mar 2017
Nature

Volume: 543, P: 424-427
FOXO transcription factors as mediators of stress adaptation

Forkhead box (FOXO) transcription factors are important mediators of cell stress responses, generally considered to preserve homeostasis and counteract ageing. However, FOXO-mediated mechanisms can also support the survival of cancer and other dysfunctional cells, thereby complicating the link between FOXOs and lifespan extension.

Maria J. Rodriguez-Colman
Tobias B. Dansen
Boudewijn. M. T. Burgering
Reviews14 Sept 2023
Nature Reviews Molecular Cell Biology

Volume: 25, P: 46-64
A guideline on the molecular ecosystem regulating ferroptosis

In this Review, Dai, Stockwell, Kroemer, Tang and colleagues offer a comprehensive discussion of the molecular regulation of ferroptosis and highlight how this may be potentially leveraged for therapeutic benefit for disease treatment.

Enyong Dai
Xin Chen
Daolin Tang
Reviews29 Feb 2024
Nature Cell Biology

Volume: 26, P: 1447-1457
Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer

M Hornsveld
M Tenhagen
P W B Derksen
Research01 Apr 2016
Cell Death & Differentiation

Volume: 23, P: 1483-1492
Stressing the role of FoxO proteins in lifespan and disease

Common regulatory enzymes affect the function of the class O of forkhead box transcription factors (FoxOs) and p53 in an opposite manner. Recent findings indicate that this shared yet opposing regulatory network between FoxOs and p53 may underlie a 'trade-off' between disease and lifespan.

Armando van der Horst
Boudewijn M.T. Burgering
Reviews01 Jun 2007
Nature Reviews Molecular Cell Biology

Volume: 8, P: 440-450
A brief introduction to FOXOlogy

B M Th Burgering
Editorial07 Apr 2008
Oncogene

Volume: 27, P: 2258-2262

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