Neurodegenerative diseases evolve in multi-factorial manners, yet coherent paradigms are emerging. Both Tau and TDP-43 proteinopathies are linked to multiple upstream influences, and both are connected with numerous deleterious downstream endpoints. Gene variants can be either disease-specific, or, exert influence on the misfolding pathology itself rather than the upstream cause.
- Yevgen Chornenkyy
- David W. Fardo
- Peter T. Nelson
