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EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.

Wendy Béguelin
Martín A. Rivas
Ari M. Melnick
ResearchOpen Access12 Oct 2017
Nature Communications

Volume: 8, P: 1-16
DLG4-related synaptopathy: a new rare brain disorder

Agustí Rodríguez-Palmero
Melissa Maria Boerrigter
Zeynep Tümer
Research17 Feb 2021
Genetics in Medicine

Volume: 23, P: 888-899
De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females

E E Palmer
T Stuhlmann
V M Kalscheuer
ResearchOpen Access23 Aug 2016
Molecular Psychiatry

Volume: 23, P: 222-230