α,α-Dideutero carboxylic acids are common precursors for isotopically labelled molecules; however, their synthesis often requires high temperatures with strong bases or precious metals. Now, the α-deuteration of carboxylic acids has been developed under mild conditions using a ternary catalyst system of K2CO3, pivalic anhydride and 4-dimethylaminopyridine.
- T. Tanaka
- Y. Koga
- T. Ohshima