Nature Search

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
PET imaging of primary mediastinal tumours

K Kubota
S Yamada
T Ido
Research01 Apr 1996
British Journal of Cancer

Volume: 73, P: 882-886
The A1 allele of the human D₂ dopamine receptor gene predicts low D₂ receptor availability in healthy volunteers

T Pohjalainen
J O Rinne
J Hietala
Research29 May 1998
Molecular Psychiatry

Volume: 3, P: 256-260
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Direct measurement of three different deformations near the ground state in an atomic nucleus

Direct measurements reveal that the neutron-deficient isotope ¹⁹⁰Pb can adopt three different deformations near the ground state. The present work identifies the collective yrast band as predominantly oblate, the non-yrast band as predominantly prolate, and discovers a candidate spherical \({2}_{3}^{+}\) state at 1281 keV.

Adrian Montes Plaza
Janne Pakarinen
George L. Zimba
ResearchOpen Access03 Jan 2025
Communications Physics

Volume: 8, P: 1-9
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

Pradeep Natarajan
Akhil Pampana
Gina M. Peloso
ResearchOpen Access12 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation

The shared genetics between upper respiratory diseases have not been well studied. Here, the authors find shared and distinct genetic loci for pharyngeal and sinonasal inflammatory conditions, which show shared heritability with autoimmune conditions and immune deficiency, highlighting the TNFR2 pathway.

Elmo C. Saarentaus
Juha Karjalainen
Aarno Palotie
ResearchOpen Access18 Jan 2023
Nature Communications

Volume: 14, P: 1-15
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Genome-wide association analyses identify 123 susceptibility loci for migraine and implicate neurovascular mechanisms in its pathophysiology. Subtype analyses highlight risk loci specific for migraine with or without aura in addition to shared risk variants.

Heidi Hautakangas
Bendik S. Winsvold
Matti Pirinen
ResearchOpen Access03 Feb 2022
Nature Genetics

Volume: 54, P: 152-160
Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

A new analysis of large biobanks uncovers genetic variants associated with longitudinal changes in medication for cardiometabolic diseases and presents polygenic scores of medication-use behavior.

Tuomo Kiiskinen
Pyry Helkkula
Samuli Ripatti
ResearchOpen Access18 Jan 2023
Nature Medicine

Volume: 29, P: 209-218
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Genetic analyses implicate complex links between adult testosterone levels and health and disease

Leinonen et al. investigate correlations between testosterone levels and disease using genetic and health registry data from the UK Biobank and FinnGen. There is a lack of evidence for normal variation in testosterone levels having a causal contribution to most non-sex-specific traits.

Jaakko T. Leinonen
Nina Mars
Taru Tukiainen
ResearchOpen Access18 Jan 2023
Communications Medicine

Volume: 3, P: 1-15
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Many genetic factors that contribute to uterine leiomyomata (UL) - the most common tumours of the female genital tract - remain to be discovered. Here, the authors conduct a UL meta-genome-wide association study, and find loci related to altered muscle tissue biology that are associated with UL.

Eeva Sliz
Jaakko S. Tyrmi
Johannes Kettunen
ResearchOpen Access01 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia.

Seyedeh M. Zekavat
Shu-Hong Lin
Pradeep Natarajan
Research07 Jun 2021
Nature Medicine

Volume: 27, P: 1012-1024
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Observation of the proton emitter \({}_{\,57}^{116}\)La₅₉

Neutron-proton pairing is a topic of continuous interest in nuclear physics and open questions remain. The authors experimentally observe direct proton decay from the ground state of odd-odd 116La, providing support for the presence of strong neutron-proton pair correlations in this exotic, neutron deficient system.

Wei Zhang
Bo Cederwall
Robert Wadsworth
ResearchOpen Access14 Nov 2022
Communications Physics

Volume: 5, P: 1-8
Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population

A genome-wide association study in a Finnish cohort identifies several new loci associated with varicose veins, including the connexin gene family member, GJD3, as a future druggable target.

Pyry Helkkula
Shabbeer Hassan
Taru Tukiainen
ResearchOpen Access18 Jan 2023
Communications Biology

Volume: 6, P: 1-12
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Therapy in old patients with isolated systolic hypertension: fourth progress report on the Syst-Eur trial

R Antikainen
J Tuomilehto
JA Staessen
Research01 May 1997
Journal of Human Hypertension

Volume: 11, P: 263-269
Reassigning the shapes of the 0⁺ states in the ¹⁸⁶Pb nucleus

The authors study an interesting phenomena of shape coexistence in ¹⁸⁶Pb. In an elegant and well-documented experiment, they confirm the coexistence of the three 0⁺ states in the ¹⁸⁶Pb nucleus and reassign the shapes associated with the excited 0⁺ states.

Joonas Ojala
Janne Pakarinen
Robert Wadsworth
ResearchOpen Access18 Aug 2022
Communications Physics

Volume: 5, P: 1-9
An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

Sanni E. Ruotsalainen
Juulia J. Partanen
Jukka Koskela
Research27 Oct 2020
European Journal of Human Genetics

Volume: 29, P: 309-324
Novel loci and biomedical consequences of iron homoeostasis variation

The largest meta-analysis of GWASs of hepcidin and sTfR identified 43 genomic loci, of which 15 new. Mendelian randomisation revealed associations of systemic iron status and iron-related loci with selected health outcomes across multiple domains.

Elias Allara
Steven Bell
Emanuele Di Angelantonio
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-17
Sigma-2 receptors as a biomarker of proliferation in solid tumours

K T Wheeler
L-M Wang
R H Mach
ResearchOpen Access22 Feb 2000
British Journal of Cancer

Volume: 82, P: 1223-1232
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Michaela Kozakova
Amalia Gastaldelli
Carlo Palombo
Research29 Apr 2020
Journal of Human Hypertension

Volume: 35, P: 334-342
Genomic prediction of alcohol-related morbidity and mortality

Tuomo Kiiskinen
Nina J. Mars
Samuli Ripatti
ResearchOpen Access21 Jan 2020
Translational Psychiatry

Volume: 10, P: 1-8
Clonal variation in interferon response determines the outcome of oncolytic virotherapy in mouse CT26 colon carcinoma model

J J Ruotsalainen
M U Kaikkonen
M J Vähä-Koskela
Research18 Sept 2014
Gene Therapy

Volume: 22, P: 65-75
Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study

P Österlund
T Ruotsalainen
H Joensuu
ResearchOpen Access25 Sept 2007
British Journal of Cancer

Volume: 97, P: 1028-1034

Search

Polygenic prediction of body mass index and obesity through the life course and across ancestries

PET imaging of primary mediastinal tumours

The A1 allele of the human D₂ dopamine receptor gene predicts low D₂ receptor availability in healthy volunteers

A saturated map of common genetic variants associated with human height

The power of genetic diversity in genome-wide association studies of lipids

Direct measurement of three different deformations near the ground state in an atomic nucleus

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Whole-genome sequencing reveals host factors underlying critical COVID-19

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

A second update on mapping the human genetic architecture of COVID-19

Genetic analyses implicate complex links between adult testosterone levels and health and disease

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Observation of the proton emitter \({}_{\,57}^{116}\)La₅₉

Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population

A first update on mapping the human genetic architecture of COVID-19

Therapy in old patients with isolated systolic hypertension: fourth progress report on the Syst-Eur trial

Reassigning the shapes of the 0⁺ states in the ¹⁸⁶Pb nucleus

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

Novel loci and biomedical consequences of iron homoeostasis variation

Sigma-2 receptors as a biomarker of proliferation in solid tumours

Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Genomic prediction of alcohol-related morbidity and mortality

Clonal variation in interferon response determines the outcome of oncolytic virotherapy in mouse CT26 colon carcinoma model

Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study

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