Familial hypercholesterolemia (FH) is an inherited disorder characterized by raised serum LDL cholesterol, which leads to accelerated atherosclerosis and a steep rise in the risk of premature coronary heart disease. Here, Anne Soutar and Rossi Naoumova examine the genetic mechanisms behind FH and discuss what effect new discoveries will have on the clinical management of FH.
- Anne K Soutar
- Rossi P Naoumova
