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ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer

While the emergence of immune checkpoint inhibitors has improved outcomes in patients with small cell lung cancer (SCLC), tumour that develop means of immune evasion become resistant. Here, the authors report that ERBB2 signalling induces loss of MHC Class I expression and subsequently immune evasion in preclinical models of SCLC.

Lydia Meder
Charlotte I. Orschel
Roland T. Ullrich
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-19
Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

Genome-wide association and multitrait analyses for dilated cardiomyopathy (DCM) using 9,365 cases and 946,368 controls provide insights into the mechanisms underlying DCM and myocardial resilience

Sean J. Jurgens
Joel T. Rämö
Connie R. Bezzina
ResearchOpen Access21 Nov 2024
Nature Genetics

Volume: 56, P: 2636-2645
EARLY SURGICAL MANAGEMENT OF A BOY WITH PERSISTENT MULLERIAN STRUCTURES

J Homoki
H Mildenberger
W M Teller
Research01 Aug 1975
Pediatric Research

Volume: 9, P: 670
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing

The Tyrolean Iceman is 5,300 years old and his mitochondrial genome has been previously sequenced. This study reports the full genome sequence of the Iceman and reveals that he probably had brown eyes, was at risk for coronary disease and may have been infected with the pathogen Lyme borreliosis.

Andreas Keller
Angela Graefen
Albert Zink
ResearchOpen Access28 Feb 2012
Nature Communications

Volume: 3, P: 1-9
Publisher Correction: Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

Sean J. Jurgens
Joel T. Rämö
Connie R. Bezzina
Amendments and CorrectionsOpen Access04 Dec 2024
Nature Genetics

Volume: 56, P: 2843
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

Kinase inhibitors are widely used to treat cancer, however patients frequently develop resistance. Here, the authors investigate adaption mechanisms during drug persistence and show that stimulation of the innate immunity sensor RIG-I enhances cancer cell death when combined with kinase inhibition.

Johannes Brägelmann
Carina Lorenz
Martin L. Sos
ResearchOpen Access17 Sept 2021
Nature Communications

Volume: 12, P: 1-15
GLUCOSE INDUCED INSULIN RELEASE FROM HUMAN FETAL ISLETS IN TISSUE CULTURE

R D G Milner
A Cser
T Allen
Research01 Aug 1975
Pediatric Research

Volume: 9, P: 672
Super enhancers define regulatory subtypes and cell identity in neuroblastoma

Westermann and colleagues define four subtypes of neuroblastoma based on super-enhancer profiles in primary patient samples, which could be linked to distinct clinical outcomes and cell identity characteristics.

Moritz Gartlgruber
Ashwini Kumar Sharma
Frank Westermann
Research07 Dec 2020
Nature Cancer

Volume: 2, P: 114-128
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect

Genome-wide analyses identify multiple loci associated with hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and left ventricular (LV) traits. Cardiomyopathies exhibit strong genetic correlations with LV traits, with opposing effects in HCM and DCM.

Rafik Tadros
Catherine Francis
Connie R. Bezzina
Research25 Jan 2021
Nature Genetics

Volume: 53, P: 128-134
Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer

Kristina Golfmann
Lydia Meder
Roland T. Ullrich
Research03 Jul 2018
Oncogene

Volume: 37, P: 5682-5693
Stimulated emission from hexagonal silicon-germanium nanowires

Hexagonal silicon-germanium features efficient direct bandgap light emission. Here, the authors demonstrate the presence of stimulated emission and optical gain in hexagonal silicon germanium and provide a roadmap to reach lasing.

Marvin A. J. van Tilburg
Riccardo Farina
Jos. E. M. Haverkort
ResearchOpen Access10 Oct 2024
Communications Physics

Volume: 7, P: 1-8
Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury

T. Meder
T. Prest
B. N. Brown
ResearchOpen Access25 Oct 2021
npj Regenerative Medicine

Volume: 6, P: 1-9
High-dose chemotherapy with autologous stem cell transplantation is an effective treatment of primary refractory Hodgkin's disease. Retrospective study of the Polish Lymphoma Research Group

J Czyż
A Hellmann
K Warzocha
Research16 Jul 2002
Bone Marrow Transplantation

Volume: 30, P: 29-34
MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27^Kip1

T Hou
J Ou
Y Zhang
ResearchOpen Access14 Jan 2014
British Journal of Cancer

Volume: 110, P: 1260-1268
A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study

Michael Altenbuchinger
Helena U. Zacharias
Wolfram Gronwald
ResearchOpen Access27 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease

Jiaojiao Jing
Arif B. Ekici
Ulla T. Schultheiss
ResearchOpen Access04 Sept 2018
Scientific Reports

Volume: 8, P: 1-9
Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort

Katharina Charlotte Reimer
Jennifer Nadal
Wolfram Gronwald
ResearchOpen Access20 Oct 2023
Bone Research

Volume: 11, P: 1-8
LIN28B enhanced tumorigenesis in an autochthonous KRAS^G12V-driven lung carcinoma mouse model

Lydia Meder
Katharina König
Roland T. Ullrich
Research05 Mar 2018
Oncogene

Volume: 37, P: 2746-2756
Associations between genetic risk variants for kidney diseases and kidney disease etiology

Sebastian Wunnenburger
Ulla T. Schultheiss
Matthias Wuttke
ResearchOpen Access24 Oct 2017
Scientific Reports

Volume: 7, P: 1-7
Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression

J-W Kornfeld
S Meder
S Riethdorf
ResearchOpen Access23 Nov 2010
British Journal of Cancer

Volume: 104, P: 138-145

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