Nature Search

Winding motion of spirals in a gravitationally unstable protoplanetary disk

ALMA telescope observations over a 7-year period have ‘filmed’ spiral arms winding in a protoplanetary disk. This motion is a hallmark of gravitational instability, a theory that suggests how giant planets might form far from their host stars.

Tomohiro C. Yoshida
Hideko Nomura
Takashi Tsukagoshi
Research24 Sept 2025
Nature Astronomy

P: 1-8
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Natural images are reliably represented by sparse and variable populations of neurons in visual cortex

Natural scenes sparsely activate V1 neurons. Here, the authors show that a small number of active cells reliably represent visual contents of a natural image across trials regardless of response variability, due to the diverse and partially overlapping representations of individual cells.

Takashi Yoshida
Kenichi Ohki
ResearchOpen Access13 Feb 2020
Nature Communications

Volume: 11, P: 1-19
Tenascin-C Modulates Adhesion of Cardiomyocytes to Extracellular Matrix during Tissue Remodeling after Myocardial Infarction

Kyoko Imanaka-Yoshida
Michiaki Hiroe
Toshimichi Yoshida
Research01 Jul 2001
Laboratory Investigation

Volume: 81, P: 1015-1024
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

Takashi Nagasawa
Seiichi Hirota
Tadamitsu Kishimoto
Research15 Aug 1996
Nature

Volume: 382, P: 635-638
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover

Retinitis pigmentosa is a genetic disease causing degeneration of retinal pigment epithelial and photoreceptor cells. Here, the authors show that PNPLA6 regulates choline metabolism for retinal homeostasis, and its dysfunction leads to degeneration, which can be rescued by choline supplementation.

Takashi Ono
Yoshitaka Taketomi
Makoto Murakami
ResearchOpen Access13 Mar 2025
Nature Communications

Volume: 16, P: 1-23
Stratified wind from a super-Eddington X-ray binary is slower than expected

The XRISM Resolve spectrum of the galactic neutron star X-ray binary, GX 13+1, reveals one of the densest winds ever seen in absorption lines.

Marc Audard
Hisamitsu Awaki
Missagh Mehdipour
ResearchOpen Access17 Sept 2025
Nature

Volume: 646, P: 57-61
Synthesis of Sulfated Deoxy-Ribofuranans Having Selective Anti-AIDS Virus Activity by Ring-Opening Copolymerization of 1,4-Anhydro Ribose Derivatives

Yoon Soung Choi
Byoung Won Kang
Toshiyuki Uryu
Research01 Apr 1997
Polymer Journal

Volume: 29, P: 374-379
Anti-AIDS Virus Activity in vitro of Dextran Sulfates Obtained by Sulfation of Synthetic and Natural Dextrans

Takashi Yoshida
Hideki Nakashima
Toshiyuki Uryu
Research01 Oct 1993
Polymer Journal

Volume: 25, P: 1069-1077
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Gene transfer and expression in progeny after intravenous DNA injection into pregnant mice

Makoto Tsukamoto
Takahiro Ochiya
Masaaki Terada
Research01 Mar 1995
Nature Genetics

Volume: 9, P: 243-248
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Discovery and dynamics of a Sedna-like object with a perihelion of 66 au

The discovery of 2023 KQ₁₄, a Sedna-like object with a perihelion of 66 au, fills a gap in the known population. Its orbit does not align with other Sedna-like objects, shedding light on the diversity and dynamical history of the outer Solar System.

Ying-Tung Chen
Patryk Sofia Lykawka
Ji-Lin Zhou
ResearchOpen Access14 Jul 2025
Nature Astronomy

Volume: 9, P: 1309-1316
In vivo Interaction of 4-Nitroquinoline-l-oxide and its Derivatives with DNA

TAIJIRO MATSUSHIMA
IKUKO KOBUNA
TAKASHI SUGIMURA
Research01 Nov 1967
Nature

Volume: 216, P: 508
Single-molecule observation of protein–protein interactions in the chaperonin system

Hideki Taguchi
Taro Ueno
Takashi Funatsu
Research01 Sept 2001
Nature Biotechnology

Volume: 19, P: 861-865
Hard magnetic ferrite with a gigantic coercivity and high frequency millimetre wave rotation

Permanent magnets based on magnetic ferrites such as Fe₃O₄ and Fe₂O₃ are used in a wide range of applications. This study demonstrates that introducing rhodium into nanoparticles consisting of the ε phase of Fe₂O₃gives rise to a very high coercivity.

Asuka Namai
Marie Yoshikiyo
Shin-ichi Ohkoshi
ResearchOpen Access04 Sept 2012
Nature Communications

Volume: 3, P: 1-6
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Selective Ring-Opening Polymerization of Di-O-t-butyldimethylsilylated and Di-O-p-bromobenzylated 1,4-Anhydro-α-L-arabinopyranoses and Structural Analysis of Free Arabinans

Takashi Yoshida
Masuo Kida
Toshiyuki Uryu
Research01 Aug 1987
Polymer Journal

Volume: 19, P: 923-931
Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression

Ho Jeong Kwon
Minoru Yoshida
Sueharu Horinouchi
Research20 Nov 1997
Oncogene

Volume: 15, P: 2625-2631
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Appropriate usage of food thickening agents to prevent non-disintegration of magnesium oxide tablets

Taisuke Matsuo
Airi Sato
Takashi Tomita
ResearchOpen Access30 Sept 2020
Scientific Reports

Volume: 10, P: 1-7
Periodontitis associated with Porphyromonas gingivalis infection is a risk factor for infertility through uterine hypertrophy

Chiaki Kamei-Nagata
Kazuhiro Omori
Shogo Takashiba
ResearchOpen Access07 Oct 2025
Scientific Reports

Volume: 15, P: 1-15
Identification of a free-N-glycan with difucosylated type-1 lactosamine in cancerous tissue and its validation for cancer diagnosis by urinary testing

Miki Tanaka-Okamoto
Ken Hanzawa
Yasuhide Miyamoto
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-10
Molecular cloning of cDNA encoding human interleukin-2 receptor

Toshio Nikaido
Akira Shimizu
Tasuku Honjo
Research18 Oct 1984
Nature

Volume: 311, P: 631-635
Essential role of Stat6 in IL-4 signalling

Kiyoshi Takeda
Takashi Tanaka
Shizuo Akira
Research18 Apr 1996
Nature

Volume: 380, P: 627-630
Synthesis and Sulfation of Branched Dextrans

Kenichi Hatanaka
Takakazu Hirobe
Toshiyuki Uryu
Research06 Apr 2005
Polymer Journal

Volume: 22, P: 435-441
Structural basis of transfer RNA processing by bacterial minimal RNase P

Transfer RNA maturation requires removal of extra sequences for proper function. Here, authors reveal how HARP, a protein-based enzyme, forms dodecamers that recognize specific tRNA features and process both 5′-leader and 3′-trailer sequences, demonstrating functional evolution.

Takamasa Teramoto
Takeshi Koyasu
Yoshimitsu Kakuta
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Intermediary Metabolites and Adenine Nucleotides in Leucocytes of Children with Protein–Calorie Malnutrition

TAKASHI YOSHIDA
JACK METCOFF
CARMEN DE LA PENA
Research01 Apr 1967
Nature

Volume: 214, P: 525-526
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in populations of East Asian ancestry.

Yingsong Lin
Masahiro Nakatochi
Keitaro Matsuo
ResearchOpen Access24 Jun 2020
Nature Communications

Volume: 11, P: 1-12
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

XBB.1.5 of SARS-CoV-2 is a descendant of XBB.1 and has mutations in spike and ORF8, making it more infectious to humans. Here, the authors examined in detail the differences in virological properties of the two variants.

Tomokazu Tamura
Takashi Irie
Takasuke Fukuhara
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-17
Sequence-regulated copolymerization based on periodic covalent positioning of monomers along one-dimensional nanochannels

Achieving sequence control in polymers is limited by the relative monomer reactivity and thus often statistically random copolymers are obtained. Here the authors show sequence control in radical polymerizations by immobilising the monomer on a porous coordination polymer and subsequent polymerization with a second free monomer.

Shuto Mochizuki
Naoki Ogiwara
Takashi Uemura
ResearchOpen Access23 Jan 2018
Nature Communications

Volume: 9, P: 1-6
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

EGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFRmutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer.

Kouya Shiraishi
Yukinori Okada
Takashi Kohno
ResearchOpen Access09 Aug 2016
Nature Communications

Volume: 7, P: 1-7
An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress

How cancer cells develop and emerge has long been a matter of debate. Here, the authors reveal a crucial role of ATR-PrimPol in enabling precancerous cells to survive KRASinduced replication stress and expand clonally with genomic instability.

Taichi Igarashi
Marianne Mazevet
Bunsyo Shiotani
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-22
Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus

Hiroyuki Toh
Hidenori Hayashida
Takashi Miyata
Research27 Oct 1983
Nature

Volume: 305, P: 827-829
Synthesis of Polymers with Adamantane Amino Derivatives as Pendant Groups

Eri Yoshida
Takashi Tsuchiya
Koji Katayama
Research01 Jan 1999
Polymer Journal

Volume: 31, P: 32-36
Clustering of CARMA1 through SH3–GUK domain interactions is required for its activation of NF-κB signalling

Activating mutations in the NF-κB regulator CARMA1 are associated with a form of B-cell lymphoma. Hara et al. show that both physiological and oncogenic CARMA1 signalling can be inhibited by preventing its activation-induced clustering, which is mediated by its SH3 and GUK domains.

Hiromitsu Hara
Tadashi Yokosuka
Takashi Saito
Research20 Jan 2015
Nature Communications

Volume: 6, P: 1-12
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Masaharu Masuda
Akihiro Sunaga
Takuya Ohashi
ResearchOpen Access30 Apr 2025
Nature Medicine

Volume: 31, P: 1661-1667
Occurrence of PER-1 Producing Clinical Isolates of Pseudomonas aeruginosa in Japan and their Susceptibility to Doripenem

Yoshinori Yamano
Toru Nishikawa
Hideaki Miwa
Research01 Dec 2006
The Journal of Antibiotics

Volume: 59, P: 791-796
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

Takashi Kohno and colleagues identify two new susceptibility loci for lung adenocarcinoma in the Japanese population. They also replicate previously identified risk loci near TERT and TP63.

Kouya Shiraishi
Hideo Kunitoh
Takashi Kohno
Research15 Jul 2012
Nature Genetics

Volume: 44, P: 900-903
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

Kazunobu Tachibana
Seiichi Hirota
Takashi Nagasawa
Research11 Jun 1998
Nature

Volume: 393, P: 591-594
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Genome-wide analysis in 212,453 Japanese individuals identifies loci associated with 42 diseases. Comparative analysis with European populations identifies East Asian–specific associations.

Kazuyoshi Ishigaki
Masato Akiyama
Yoichiro Kamatani
Research08 Jun 2020
Nature Genetics

Volume: 52, P: 669-679
Long-lasting gene expression by particle-mediated intramuscular transfection modified with bupivacaine: combinatorial gene therapy with IL-12 and IL-18 cDNA against rat sarcoma at a distant site

Takashi Ajiki
Takashi Murakami
Eiji Kobayashi
Research04 Apr 2003
Cancer Gene Therapy

Volume: 10, P: 318-329
Abnormalities of Carbamyl Phosphate Synthetase and Ornithine Transcarbamylase in Liver of Patients with Reye's Syndrome

Frank Sinatra
Takashi Yoshida
Philip Sunshine
Research01 Nov 1975
Pediatric Research

Volume: 9, P: 829-833
Is the AIDS virus recombinant?

HIROYUKI TOH
TAKASHI MIYATA
Research04 Jul 1985
Nature

Volume: 316, P: 21-22
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

Naoki Kunishima
Yoshimi Shimada
Kosuke Morikawa
Research26 Oct 2000
Nature

Volume: 407, P: 971-977
One-dimensional imidazole aggregate in aluminium porous coordination polymers with high proton conductivity

Anhydrous proton-conducting materials capable of operating at high temperature are required for fuel-cell applications. Encapsulation of a proton-carrier imidazole molecule in aluminium porous coordination polymers in anhydrous conditions results in high proton conductivity above 100 ^∘C.

Sareeya Bureekaew
Satoshi Horike
Susumu Kitagawa
Research06 Sept 2009
Nature Materials

Volume: 8, P: 831-836

Search

Filter By:

Search

Quick links