Nature Search

Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc

Holger Karsunky
Christoph Geisen
Tarik Möröy
Research04 Jan 2000
Oncogene

Volume: 18, P: 7816-7824
Loss of p27^Kip1 cooperates with cyclin E in T-cell lymphomagenesis

Christoph Geisen
Holger Karsunky
Tarik Möröy
Research18 Mar 2003
Oncogene

Volume: 22, P: 1724-1729
Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.

Peiman Shooshtarizadeh
Anne Helness
Tarik Möröy
ResearchOpen Access20 Mar 2019
Nature Communications

Volume: 10, P: 1-16
Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks

Tarik Möröy
Agnés Marchio
Marie-Annick Buendia
Research20 Nov 1986
Nature

Volume: 324, P: 276-279
Inhibition of Poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice

Ralph Beneke
Tarik Möröy
Research11 Dec 2001
Oncogene

Volume: 20, P: 8136-8141
More clues to gene rearrangements

TARIK MÖRÖY
MICHELLE HADCHOUEL
MARIE-ANNICK BUENDIA
Research29 Jan 1987
Nature

Volume: 325, P: 396
Features of systemic lupus erythematosus in Dnase1-deficient mice

Markus Napirei
Holger Karsunky
Tarik Möröy
Research01 Jun 2000
Nature Genetics

Volume: 25, P: 177-181
Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1

Holger Karsunky
Hui Zeng
Tarik Möröy
Research28 Jan 2002
Nature Genetics

Volume: 30, P: 295-300
GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

The transcription factor GFI1 mediates the DNA damage response (DDR) of T cells through a yet unknown mechanism. Here the authors show that GFI1 can adopt non-transcriptional roles during DDR, enabling PRMT1 to bind and methylate the DNA repair proteins MRE11 and 53BP1.

Charles Vadnais
Riyan Chen
Tarik Möröy
ResearchOpen Access12 Apr 2018
Nature Communications

Volume: 9, P: 1-14
Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

Florian Heyd
Gerdy ten Dam
Tarik Möröy
Research02 Jul 2006
Nature Immunology

Volume: 7, P: 859-867
Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis

Thorsten Schmidt
Holger Karsunky
Tarik Möröy
Research19 Oct 1998
Oncogene

Volume: 17, P: 2661-2667
GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

Helness et al. show that GFI1/CHD4 complexes critically regulate chromatin accessibility and histone modifications to regulate target genes affecting diverse cellular processes in neutrophils. Their results provide further insight into the molecular network operated by GFI1 for neutrophil differentiation programs.

Anne Helness
Jennifer Fraszczak
Tarik Möröy
ResearchOpen Access02 Dec 2021
Communications Biology

Volume: 4, P: 1-16
Author Correction: GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

Anne Helness
Jennifer Fraszczak
Tarik Möröy
Amendments and CorrectionsOpen Access07 Sept 2022
Communications Biology

Volume: 5, P: 1
Repression of p15^INK4b expression by Myc through association with Miz-1

Peter Staller
Karen Peukert
Martin Eilers
Research13 Mar 2001
Nature Cell Biology

Volume: 3, P: 392-399
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

Lacaud and colleagues show that the GFI1 transcriptional repressors are required for endothelial-to-haematopoietic transition in the aorta–gonad–mesonephros region of the mouse embryo by inhibiting the endothelial gene expression program via LSD1.

Roshana Thambyrajah
Milena Mazan
Georges Lacaud
Research30 Nov 2015
Nature Cell Biology

Volume: 18, P: 21-32
High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells

Holger Karsunky
Ines Mende
Tarik Möröy
Research27 Feb 2002
Oncogene

Volume: 21, P: 1571-1579
Sulindac sulfide inhibits Ras signaling

Christian Herrmann
Christoph Block
Oliver Müller
Research09 Oct 1998
Oncogene

Volume: 17, P: 1769-1776
Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4

Kirsten Haas
Christian Johannes
Tarik Möröy
Research20 Nov 1997
Oncogene

Volume: 15, P: 2615-2623
Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation

Katja Braun
Gabriele Hölzl
Markus Hengstschläger
Research29 Oct 1998
Oncogene

Volume: 17, P: 2259-2269
Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16^INK4A as upstream regulators of Myc

Kirsten Haas
Peter Staller
Tarik Möröy
Research10 Jul 1997
Oncogene

Volume: 15, P: 179-192
The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

Thorsten Schmidt
Kathrin Körner
Tarik Möröy
Research29 Sept 1999
Cell Death & Differentiation

Volume: 6, P: 873-882
Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

Jennifer Fraszczak
Charles Vadnais
Tarik Möröy
ResearchOpen Access20 Jun 2018
Leukemia

Volume: 33, P: 110-121
A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells

Charles Vadnais
Riyan Chen
Tarik Möröy
ResearchOpen Access19 Apr 2019
Scientific Reports

Volume: 9, P: 1-9
Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells

Marie-Claude Gaudreau
Damien Grapton
Tarik Möröy
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-15
Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

René Winkler
Ann-Sophie Mägdefrau
Christian Kosan
ResearchOpen Access06 Sept 2022
Oncogene

Volume: 41, P: 4560-4572
GFI1 as a novel prognostic and therapeutic factor for AML/MDS

J M Hönes
L Botezatu
C Khandanpour
Research05 Feb 2016
Leukemia

Volume: 30, P: 1237-1245
Identification of Tcf-4 as a transcriptional target of p53 signalling

Karen Rother
Cindy Johne
Kurt Engeland
Research01 Mar 2004
Oncogene

Volume: 23, P: 3376-3384

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Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc

Loss of p27^Kip1 cooperates with cyclin E in T-cell lymphomagenesis

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks

Inhibition of Poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice

More clues to gene rearrangements

Features of systemic lupus erythematosus in Dnase1-deficient mice

Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis

GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

Author Correction: GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

Repression of p15^INK4b expression by Myc through association with Miz-1

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells

Sulindac sulfide inhibits Ras signaling

Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4

Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation

Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16^INK4A as upstream regulators of Myc

The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells

Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

GFI1 as a novel prognostic and therapeutic factor for AML/MDS

Identification of Tcf-4 as a transcriptional target of p53 signalling

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