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Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

Tadahiro Kitamura
Yun Feng
Domenico Accili
Research09 Apr 2006
Nature Medicine

Volume: 12, P: 534-540
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

Jun Nakae
William H. Biggs III
Domenico Accili
Research03 Sept 2002
Nature Genetics

Volume: 32, P: 245-253
The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

Resistance to insulin leads to type 2 diabetes mellitus (T2DM) but only when accompanied by pancreatic β-cell dysfunction. This Review describes the molecular mechanisms associated with pancreatic β-cell dysfunction in T2DM and discusses how modulating FOXO1 activity might serve as a new therapeutic target to treat T2DM.

Tadahiro Kitamura
Reviews20 Aug 2013
Nature Reviews Endocrinology

Volume: 9, P: 615-623
Autonomous membrane IgE signaling prevents IgE-memory formation

Under normal conditions, IgE⁺ memory B cells and IgE serum antibody are extremely scarce. Kitamura and colleagues demonstrate that the IgE B cell receptor has unique signaling properties that autonomously control IgE⁺ B cell numbers.

Kei Haniuda
Saori Fukao
Daisuke Kitamura
Research18 Jul 2016
Nature Immunology

Volume: 17, P: 1109-1117
Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

SIRT1 is a NAD⁺-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated by FGF21 signalling and oxytocin.

Sho Matsui
Tsutomu Sasaki
Tadahiro Kitamura
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-17
Generation of functional insulin-producing cells in the gut by Foxo1 ablation

Domenico Accili and colleagues report that somatic ablation of Foxo1 in enteroendocrine progenitor cells leads to gut insulin-positive cells that have hallmarks of mature pancreatic β cells. Inactivating Foxo1 in the gut epithelium might provide a therapeutic mechanism for restoring insulin production in type 1 diabetes.

Chutima Talchai
Shouhong Xuan
Domenico Accili
Research11 Mar 2012
Nature Genetics

Volume: 44, P: 406-412
Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load

Naoki Kuramoto
Kazuhiro Nomura
Wataru Ogawa
ResearchOpen Access10 Feb 2021
Scientific Reports

Volume: 11, P: 1-10

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Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

Autonomous membrane IgE signaling prevents IgE-memory formation

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load

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Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

Autonomous membrane IgE signaling prevents IgE-memory formation

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load

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