Grazyna Palczewska and her colleagues use the noninvasive imaging modality of two-photon microscropy to study the retinoid cycle in the mammalian eye at the subcellular level. They perform spectral analyses of endogenous fluorophores, including fluorescent retinyl esters in subcellular structures called retinosomes, as well as their potentially harmful condensation products. This may prove useful in assessing retinal changes in the human eye at the earliest stage and long before retinal diseases become apparent and result in loss of vision.
- Grazyna Palczewska
- Tadao Maeda
- Krzysztof Palczewski
