Nature Search

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

Fumio Sakane
Keiko Yamada
Tadashi Tanabe
Research22 Mar 1990
Nature

Volume: 344, P: 345-348
Molecular and Genetic Analyses of Two Patients with Pearson's Marrow-Pancreas Syndrome

Tadashi Sano
Kyoko Ban
Takayuki Ozawa
Research01 Jul 1993
Pediatric Research

Volume: 34, P: 105-110
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Interstitial deletion of the long ARM of chromosome 2: A dose study on isocitrate dehydrogenase 1

Satoshi Sumi
Mikihisa Obayashi
Nobuaki Ogasawara
Research01 Dec 1988
Japanese journal of human genetics

Volume: 33, P: 461-467
Conformation of Liquid Silk Sericin

Masuhiro Tsukada
Tadashi Komoto
Tohru Kawai
Research01 Jun 1979
Polymer Journal

Volume: 11, P: 503-505
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
A regulator of transcriptional elongation controls vertebrate neuronal development

Su Guo
Yuki Yamaguchi
Arnon Rosenthal
Research16 Nov 2000
Nature

Volume: 408, P: 366-369
Chiral symmetry restoration at high matter density observed in pionic atoms

In quantum chromodynamics, the condensation of quark–antiquark pairs breaks the chiral symmetry of vacuum. Experiments with pionic tin atoms demonstrate that the symmetry is partially restored at high densities.

Takahiro Nishi
Kenta Itahashi
Koichi Yoshida
Research23 Mar 2023
Nature Physics

Volume: 19, P: 788-793
CO₂ phonon mode renormalization using phonon-assisted energy up-conversion

Nabila Tanjeem
Tadashi Kawazoe
Takashi Yatsui
ResearchOpen Access26 Nov 2013
Scientific Reports

Volume: 3, P: 1-8
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1

Masao Murakami
Martha H Sonobe
Hideo Iba
Research22 May 1997
Oncogene

Volume: 14, P: 2435-2444
Carnitine/organic cation transporter 1 precipitates the progression of interstitial fibrosis through oxidative stress in diabetic nephropathy in mice

Shohei Makiishi
Kengo Furuichi
Takashi Wada
ResearchOpen Access27 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Real-time observation of X-ray-induced intramolecular and interatomic electronic decay in CH₂I₂

Understanding strong X-ray induced phenomena is important for applications of X-ray free-electron laser imaging. Here, the authors show time-resolved measurements of X-ray free-electron laser induced electronic decay of CH₂I₂ molecule probed with NIR pulses and identify mechanisms behind different transient states lifetimes.

Hironobu Fukuzawa
Tsukasa Takanashi
Kiyoshi Ueda
ResearchOpen Access16 May 2019
Nature Communications

Volume: 10, P: 1-8
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
TAG-1–assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding

The authors show that shortening of the basal process in neural progenitor cells by depletion of TAG-1 results in overcrowding in the periventricular space and, eventually, delamination and aberrant migration. These results suggest that one of the functions of interkinetic nuclear migration is to prevent progenitor congestion and mechanical stress.

Mayumi Okamoto
Takashi Namba
Takaki Miyata
Research22 Sept 2013
Nature Neuroscience

Volume: 16, P: 1556-1566
Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Questioning what regulates left-right asymmetry breaking in the mouse node: the authors identify a 200 bp stretch of the Dand5 3’UTR where Bicc1 binds, and Cnot proteins downstream of calcium flow regulate the post-transcriptional regulation of Dand5 by Bicc1.

Katsura Minegishi
Benjamin Rothé
Hiroshi Hamada
ResearchOpen Access01 Jul 2021
Nature Communications

Volume: 12, P: 1-17
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Chymase Inhibition Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction in Rats

Hideo Kanemitsu
Shinji Takai
Masashi Komeda
Research01 Jan 2006
Hypertension Research

Volume: 29, P: 57-64
Increased levels of oral Streptococcus-derived d-alanine in patients with chronic kidney disease and diabetes mellitus

Yusuke Nakade
Yasunori Iwata
Takashi Wada
ResearchOpen Access16 Dec 2022
Scientific Reports

Volume: 12, P: 1-12
A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart

Ayaka Kitamura
Ryohei Takata
Tadashi Wada
ResearchOpen Access16 Apr 2018
Scientific Reports

Volume: 8, P: 1-9
Trajectories of kidney function in diabetes: a clinicopathological update

The clinical course of diabetic kidney disease can follow different trajectories of albuminuria and glomerular filtration rate. In this Review, the authors discuss these trajectories and their underlying factors, as well as their correlation with histopathological changes in the kidney and patient outcomes.

Megumi Oshima
Miho Shimizu
Takashi Wada
Reviews06 Aug 2021
Nature Reviews Nephrology

Volume: 17, P: 740-750
Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study

Shimon Kurasawa
Yoshinari Yasuda
Kiyoyuki Tokuyama
Research18 Jul 2023
Hypertension Research

Volume: 46, P: 2478-2487
A comprehensive risk factor analysis using association rules in people with diabetic kidney disease

Tadashi Toyama
Miho Shimizu
Yasunori Iwata
ResearchOpen Access20 Jul 2023
Scientific Reports

Volume: 13, P: 1-9
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

Taito Miyake
Norihiko Sakai
Takashi Wada
ResearchOpen Access31 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
Identification of candidate PAX2-regulated genes implicated in human kidney development

Yuta Yamamura
Kengo Furuichi
Takashi Wada
ResearchOpen Access27 Apr 2021
Scientific Reports

Volume: 11, P: 1-13
The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage

Norihiko Sakai
Gretchen Bain
Takashi Wada
ResearchOpen Access15 May 2019
Scientific Reports

Volume: 9, P: 1-14
J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan

Naoki Nakagawa
Tadashi Sofue
Naoki Kashihara
ResearchOpen Access30 Apr 2020
Scientific Reports

Volume: 10, P: 1-11
Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis

Norihiko Sakai
Miki Nakamura
Takashi Wada
ResearchOpen Access14 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Photoelectron diffraction from laser-aligned molecules with X-ray free-electron laser pulses

Kyo Nakajima
Takahiro Teramoto
Akira Yagishita
ResearchOpen Access15 Sept 2015
Scientific Reports

Volume: 5, P: 1-11
Structure determination of molecules in an alignment laser field by femtosecond photoelectron diffraction using an X-ray free-electron laser

Shinichirou Minemoto
Takahiro Teramoto
Akira Yagishita
ResearchOpen Access09 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17

Search

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

Molecular and Genetic Analyses of Two Patients with Pearson's Marrow-Pancreas Syndrome

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

Interstitial deletion of the long ARM of chromosome 2: A dose study on isocitrate dehydrogenase 1

Conformation of Liquid Silk Sericin

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

A regulator of transcriptional elongation controls vertebrate neuronal development

Chiral symmetry restoration at high matter density observed in pionic atoms

CO₂ phonon mode renormalization using phonon-assisted energy up-conversion

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1

Carnitine/organic cation transporter 1 precipitates the progression of interstitial fibrosis through oxidative stress in diabetic nephropathy in mice

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Real-time observation of X-ray-induced intramolecular and interatomic electronic decay in CH₂I₂

Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

TAG-1–assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Chymase Inhibition Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction in Rats

Increased levels of oral Streptococcus-derived d-alanine in patients with chronic kidney disease and diabetes mellitus

A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart

Trajectories of kidney function in diabetes: a clinicopathological update

Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study

A comprehensive risk factor analysis using association rules in people with diabetic kidney disease

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

Identification of candidate PAX2-regulated genes implicated in human kidney development

The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage

J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan

Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis

Photoelectron diffraction from laser-aligned molecules with X-ray free-electron laser pulses

Structure determination of molecules in an alignment laser field by femtosecond photoelectron diffraction using an X-ray free-electron laser

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

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