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Showing 1–4 of 4 results

Advanced filters: Author: Tae-In Kam Clear advanced filters

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Changes in autophagy have been shown to modulate lifespan in lower organisms. Here, Pyo et al.show that mice globally overexpressing the autophagy protein Atg5 live longer and are leaner than normal mice, providing the first evidence that increased autophagy extends lifespan in mammals.

Jong-Ok Pyo
Seung-Min Yoo
Yong-Keun Jung
ResearchOpen Access13 Aug 2013
Nature Communications

Volume: 4, P: 1-9
α-Synuclein pathology as a target in neurodegenerative diseases

In this Review, the authors provide a comprehensive overview of our current understanding of the involvement of α-synuclein in neurodegenerative diseases and highlight therapeutic approaches that target pathological α-synuclein.

Hyejin Park
Tae-In Kam
Ted M. Dawson
Reviews28 Nov 2024
Nature Reviews Neurology

Volume: 21, P: 32-47
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.

Seung Pil Yun
Tae-In Kam
Han Seok Ko
Research11 Jun 2018
Nature Medicine

Volume: 24, P: 931-938
MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease

Yoon Sun Chun
Mi-Yeon Kim
Sungho Han
ResearchOpen Access10 Aug 2022
Molecular Psychiatry

Volume: 27, P: 4770-4780