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Showing 1–2 of 2 results
Advanced filters: Author: Taegwon Oh Clear advanced filters

  • Loss of major histocompatibility complex MHC-I expression contributes to cancer immune evasion. Here, the authors show that, in both mice and humans, MHC-I downregulation is associated with the induction of NK-cell exhaustion and that IL-21 restores NK-cell function and inhibits tumours progression.

    • Hyungseok Seo
    • Insu Jeon
    • Chang-Yuil Kang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Tuberculosis kills more than a million people annually, and new treatments are necessary to counter the spread of drug-resistant forms of Mycobacterium tuberculosis. In this issue, Kevin Pethe and his colleagues report their identification of a new antibercular drug, called Q203, that targets the mycobacterial cytochrome bc1 complex and that showed efficacy in vitro and in vivo.

    • Kevin Pethe
    • Pablo Bifani
    • Jaeseung Kim
    Research
    Nature Medicine
    Volume: 19, P: 1157-1160