Characterization of plasma membrane proteins is important in understanding fundamental biological processes and developing new drugs, but their separation remains a challenge. Now, a synthetic receptor–ligand pair based on ferrocene derivatives and cucurbit[7]uril is shown to have exceptionally high binding affinity, and enables membrane proteins to be isolated efficiently without any contamination from naturally biotinylated molecules.
- Don-Wook Lee
- Kyeng Min Park
- Kimoon Kim
