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Nature Immunology (3)
Journal of Human Genetics (1)
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Showing 1–5 of 5 results

Advanced filters: Author: Taisho Yamada Clear advanced filters

Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defense

The aryl hydrocarbon receptor (AHR) has well-described roles in the differentiation of T cells; however, less is known about its function in innate immunity. Takaoka and colleagues demonstrate how an AHR-dependent pathway reins in production of type I interferon.

Taisho Yamada
Hiromasa Horimoto
Akinori Takaoka
Research18 Apr 2016
Nature Immunology

Volume: 17, P: 687-694
Bioimpedance analysis for identifying new indicators of exercise-induced muscle damage

Shota Yamaguchi
Takayuki Inami
Naohiko Kohtake
ResearchOpen Access03 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

Poly(ADP-ribose) polymerases participate in many biological and pathological processes. Takaoka and co-workers show that the short isoform of PARP-13 (ZAPS) is selectively induced by 5'-triphosphate–modified RNA and regulates signaling mediated by the RNA helicase RIG-I.

Sumio Hayakawa
Souichi Shiratori
Akinori Takaoka
Research21 Nov 2010
Nature Immunology

Volume: 12, P: 37-44
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

RIG-I is a cytosolic nucleic acid sensor triggering type I IFN production. Takaoka and colleagues find that RIG-I recognizes SARS-CoV-2 RNA in a noncanonical manner and fails to activate type I IFN, but it directly restricts viral replication.

Taisho Yamada
Seiichi Sato
Akinori Takaoka
Research11 May 2021
Nature Immunology

Volume: 22, P: 820-828
Japan PGx Data Science Consortium Database: SNPs and HLA genotype data from 2994 Japanese healthy individuals for pharmacogenomics studies

Shigeo Kamitsuji
Takashi Matsuda
Shyh-Yuh Liou
Research09 Apr 2015
Journal of Human Genetics

Volume: 60, P: 319-326