Nature Search

Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Tsuyoshi Iizuka
Takazo Shibuya
Hisayoshi Yurimoto
Research10 Sept 2025
Nature

Volume: 646, P: 62-67
Microbiological Transformation of a Cardiac Aglycone

HAYAO NAWA
MASAO UCHIBAYASHI
MATAZO ABE
Research08 Aug 1959
Nature

Volume: 184, P: 469-470
Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance

Takaaki Ozawa
Issei Nakagawa
Takatoshi Hikida
ResearchOpen Access30 Sept 2025
npj Science of Food

Volume: 9, P: 1-13
Renal Artery Dissection after Angiographic Evaluation of Lower Extremities

Masayuki Tanemoto
Michiaki Abe
Sadayoshi Ito
Research01 Oct 2005
Hypertension Research

Volume: 28, P: 853-855
Sports-related spinal cord injury in Japan (From the nationwide spinal cord injury registry between 1990 and 1992)

Shinsuke Katoh
Hikosuke Shingu
Eiji Iwatsubo
Research01 Jul 1996
Spinal Cord

Volume: 34, P: 416-421
Predictors of Undiagnosed Renal Artery Stenosis among Japanese Patients with Risk Factors of Atherosclerosis

Masayuki Tanemoto
Harutaka Saitoh
Sadayoshi Ito
Research01 Mar 2005
Hypertension Research

Volume: 28, P: 237-242
Chemical evolution of primordial salts and organic sulfur molecules in the asteroid 162173 Ryugu

The asteroid Ryugu samples are by far the freshest extraterrestrial carbonaceous material. The authors report soluble ions and organic sulfur molecules linked with primordial brine and prebiotic organic evolution of the primitive asteroid.

Toshihiro Yoshimura
Yoshinori Takano
Yuki Kimura
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-11
Carbonate record of temporal change in oxygen fugacity and gaseous species in asteroid Ryugu

The asteroid Ryugu experienced aqueous alteration under changing temperature and redox conditions, according to an isotopic analysis of secondary calcite and dolomite grains in samples from Ryugu obtained by the Hayabusa2 spacecraft.

Wataru Fujiya
Noriyuki Kawasaki
Hisayoshi Yurimoto
Research10 Jul 2023
Nature Geoscience

Volume: 16, P: 675-682
Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

A comparison of copper and zinc isotopic measurements between the Ryugu samples and various carbonaceous chondrites excludes any genetic link between the two except for the CI (Ivuna-type) chondrites. Ryugu-like material might have accounted for ~5% of Earth’s mass.

Marine Paquet
Frederic Moynier
Hisayoshi Yurimoto
Research12 Dec 2022
Nature Astronomy

Volume: 7, P: 182-189
Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu

In this study, the authors report primordial aqueous alteration signatures in water-soluble organic molecules from the carbonaceous asteroid Ryugu. This provides evidence o coevolutionary aqueous alteration between water and organics in this asteroid.

Yoshinori Takano
Hiroshi Naraoka
Shogo Tachibana
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Dilation of Renal Artery Stenosis after Administration of Losartan

Masayuki Tanemoto
Kei Takase
Sadayoshi Ito
Research01 Oct 2007
Hypertension Research

Volume: 30, P: 999-1002
A dehydrated space-weathered skin cloaking the hydrated interior of Ryugu

A close-up look at the action of space weathering on carbonaceous asteroids, provided by Ryugu’s returned samples, highlights its role on the dehydration of the first micrometre-thick layer of the surface, possibly hiding a water-rich interior. The depth of the 2.7 µm hydration band may be an indication of the level of space weathering withstood by a C-type asteroid.

Takaaki Noguchi
Toru Matsumoto
Yuichi Tsuda
ResearchOpen Access19 Dec 2022
Nature Astronomy

Volume: 7, P: 170-181
SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

Katsuumi, Shimizu, Suda et al. report that SGLT2 inhibition reduces the senescence burden and alleviates aging traits in mice. The authors demonstrate an indirect mechanism of senescent cell removal, through enhancing immunosurveillance.

Goro Katsuumi
Ippei Shimizu
Tohru Minamino
ResearchOpen Access30 May 2024
Nature Aging

Volume: 4, P: 926-938
High glucose level and angiotensin II type 1 receptor stimulation synergistically amplify oxidative stress in renal mesangial cells

Tetsuya Akaishi
Michiaki Abe
Sadayoshi Ito
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-7
Breunnerite grain and magnesium isotope chemistry reveal cation partitioning during aqueous alteration of asteroid Ryugu

Returned samples from the carbonaceous asteroid Ryugu provide pristine information on the original aqueous alteration history of the Solar System. Here, the authors utilize Breunnerite grain and magnesium isotope chemistry to reveal cation partitioning during aqueous alteration of asteroid Ryugu.

Toshihiro Yoshimura
Daisuke Araoka
Yoshinori Takano
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Variations of organic functional chemistry in carbonaceous matter from the asteroid 162173 Ryugu

A new study of samples from the Ryugu asteroid reveal a greater diversity of macromolecular organic matter than that found in related carbonaceous meteorites. Researchers find distinct populations of alkyl-aromatic grains, and organic carbonate is found with coarse-grained clay minerals

Bradley De Gregorio
George D. Cody
Yuichi Tsuda
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

Marine Paquet
Frederic Moynier
Hisayoshi Yurimoto
Amendments and Corrections14 Mar 2023
Nature Astronomy

Volume: 7, P: 633
Angiographic Index for Angioplasty-Treatable Atheromatous Renal Artery Stenosis

Masayuki Tanemoto
Michiaki Abe
Sadayoshi Ito
Research01 May 2008
Hypertension Research

Volume: 31, P: 881-885
Nonmagnetic framboid and associated iron nanoparticles with a space-weathered feature from asteroid Ryugu

Electron holography discovered nonmagnetic framboids and many iron nanoparticles with a vortex magnetic flux formed by magnetite reduction due to a micrometeoroid impact on asteroid Ryugu, providing a new way to study the Solar System magnetic field.

Yuki Kimura
Takeharu Kato
Shogo Tachibana
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-11
Longitudinal association of oral functions and dementia in Japanese older adults

Komei Iwai
Tetsuji Azuma
Takaaki Tomofuji
ResearchOpen Access11 Mar 2024
Scientific Reports

Volume: 14, P: 1-8
Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

Mieko Onuki
Yukio Iwamura
Hideo Hamaguchi
Research23 Jun 2005
Japanese journal of human genetics

Volume: 31, P: 337-343
Ratio of diastolic to systolic blood pressure represents renal resistive index

Tetsuya Akaishi
Michiaki Abe
Tadashi Ishii
ResearchOpen Access04 Oct 2019
Journal of Human Hypertension

Volume: 34, P: 512-519
Influx of nitrogen-rich material from the outer Solar System indicated by iron nitride in Ryugu samples

Iron nitride (Fe₄N) is detected on magnetite particles within the Ryugu sample returned by Hayabusa2. It is probably the product of impacts of nitrogen-rich dust from the outer Solar System on the surface of Ryugu, indicative of a flux of N-rich dust in the inner Solar System.

Toru Matsumoto
Takaaki Noguchi
Yuichi Tsuda
ResearchOpen Access30 Nov 2023
Nature Astronomy

Volume: 8, P: 207-215
Soluble organic matter Molecular atlas of Ryugu reveals cold hydrothermalism on C-type asteroid parent body

The molecular atlas of soluble organic compounds from Ryugu shows unprecedented molecular complexity and diversity resulting from alteration on a low temperature, water rich parent body.

Philippe Schmitt-Kopplin
Norbert Hertkorn
Yasuhiro Oba
ResearchOpen Access16 Oct 2023
Nature Communications

Volume: 14, P: 1-9
Uracil in the carbonaceous asteroid (162173) Ryugu

Uracil was identified in the sample returned from the asteroid Ryugu. Having been provided to the early Earth as a component in such asteroidal materials, these molecules might have played a role for prebiotic chemical evolution on the early Earth

Yasuhiro Oba
Toshiki Koga
Yuichi Tsuda
ResearchOpen Access21 Mar 2023
Nature Communications

Volume: 14, P: 1-9
Chondrule-like objects and Ca-Al-rich inclusions in Ryugu may potentially be the oldest Solar System materials

Chondrule-like objects and CAIs in the Ryugu samples are early generations of chondrules and possibly oldest solids in the Solar System. They were transported from the inner solar nebula to the formation location of the Ryugu original parent body.

Daisuke Nakashima
Tomoki Nakamura
Yuichi Tsuda
ResearchOpen Access16 Feb 2023
Nature Communications

Volume: 14, P: 1-9
A history of mild shocks experienced by the regolith particles on hydrated asteroid Ryugu

Signatures of impact-induced shocks are found on Ryugu returned particles. Observations show that they happened at moderate temperatures (~500 °C) and pressures (~2 GPa) and did not dehydrate the particles substantially, suggesting that bigger meteoroids, rather than micrometeoroids, provide Earth with hydrated minerals.

Naotaka Tomioka
Akira Yamaguchi
Yuichi Tsuda
ResearchOpen Access20 Apr 2023
Nature Astronomy

Volume: 7, P: 669-677
The developmental basis of bat wing muscle

Phylogenetic bat studies suggest that powered flight is evolutionarily conserved. Tokita et al.find that bat wing muscles are derived from multiple myogenic sources with different embryonic origins, and that spatiotemporal correlations exist between outgrowth of wing membranes and expansion of wing muscles.

Masayoshi Tokita
Takaaki Abe
Kazuo Suzuki
Research18 Dec 2012
Nature Communications

Volume: 3, P: 1-9
A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Biochemical and lipidomic analyses identify an anti-ferroptotic function of vitamin K and reveal ferroptosis suppressor protein 1 (FSP1) as the enzyme mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle.

Eikan Mishima
Junya Ito
Marcus Conrad
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: 778-783
Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney

Tomoyuki Iwasaki
Eikan Mishima
Takaaki Abe
Research22 May 2020
Hypertension Research

Volume: 43, P: 1214-1221
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.

Koichi Kikuchi
Daisuke Saigusa
Takaaki Abe
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-17
Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients

Yoshiyasu Tongu
Tomoko Kasahara
Takaaki Abe
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-14
Characterization of two types of cesium-bearing microparticles emitted from the Fukushima accident via multiple synchrotron radiation analyses

Hikaru Miura
Yuichi Kurihara
Yoshio Takahashi
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-9
Localization of Aldosterone-Producing Adrenocortical Adenomas: Significance of Adrenal Venous Sampling

Fumitoshi Satoh
Takaaki Abe
Sadayoshi Ito
Research01 Nov 2007
Hypertension Research

Volume: 30, P: 1083-1095
Preliminary analysis of the Hayabusa2 samples returned from C-type asteroid Ryugu

The Hayabusa2 spacecraft returned 5.4 g of material from the asteroid Ryugu. A first analysis of the samples found an estimated density of 1,282 ± 231 kg m⁻³, considerably lower than even the most porous meteorites. Together with preliminary spectral analysis, these results indicate that Ryugu is similar to CI chondrites, but darker, more porous and more brittle.

Toru Yada
Masanao Abe
Yuichi Tsuda
ResearchOpen Access20 Dec 2021
Nature Astronomy

Volume: 6, P: 214-220
Novel ACTG1 mutations in patients identified by massively parallel DNA sequencing cause progressive hearing loss

Hiroki Miyajima
Hideaki Moteki
Shin-ichi Usami
ResearchOpen Access27 Apr 2020
Scientific Reports

Volume: 10, P: 1-10
Renal anemia and hyporesponsiveness to ESA for preservation of residual kidney function in patients undergoing peritoneal dialysis

Takahiro Imaizumi
Takeshi Hasegawa
Takahiro Kuragano
ResearchOpen Access21 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways

Daisuke Kato
Hiroyuki Kameda
Kohsuke Kudo
ResearchOpen Access14 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca²⁺ overload in Caenorhabditis elegans

XinTong Wu
Miku Seida
Atsushi Higashitani
ResearchOpen Access01 Aug 2023
npj Aging

Volume: 9, P: 1-5
Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range

Junichi Hata
Ken Nakae
Hideyuki Okano
ResearchOpen Access27 Apr 2023
Scientific Data

Volume: 10, P: 1-8
Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks

Kie Ozaki
Reona Kato
Motohiro Yamauchi
ResearchOpen Access08 Aug 2024
Scientific Reports

Volume: 14, P: 1-15
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Metabolomic profiling of uremic solutes in CKD patients

Takafumi Toyohara
Yasutoshi Akiyama
Takaaki Abe
Research08 Jul 2010
Hypertension Research

Volume: 33, P: 944-952
Stage of chronic kidney disease is an outcome-predicting factor of angioplasty for atheromatous renal artery stenosis

Masayuki Tanemoto
Yoichi Takeuchi
Sadayoshi Ito
Research12 Aug 2010
Hypertension Research

Volume: 33, P: 1206-1210
Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth

Akane Suda
Banlanjo Abdulaziz Umaru
Yoshiteru Kagawa
ResearchOpen Access22 Feb 2024
Scientific Reports

Volume: 14, P: 1-16
Space weathering acts strongly on the uppermost surface of Ryugu

Samples returned from Ryugu contain fresher material than the space weathered outer asteroid surface observed by remote sensing, according to a comparison of spectral data from returned samples, orbital observations and Murchison meteorite samples.

Moe Matsuoka
Ei-ichi Kagawa
Yuichi Tsuda
ResearchOpen Access27 Sept 2023
Communications Earth & Environment

Volume: 4, P: 1-12
Urinary growth differentiation factor 15 predicts renal function decline in diabetic kidney disease

Toma Oshita
Shun Watanabe
Takaaki Abe
ResearchOpen Access02 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Visualization of nanoscale magnetic domain states in the asteroid Ryugu

Yuki Kimura
Takeharu Kato
Shogo Tachibana
ResearchOpen Access29 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
Erratum: Metabolomic profiling of uremic solutes in CKD patients

Takafumi Toyohara
Yasutoshi Akiyama
Takaaki Abe
Amendments and Corrections05 Oct 2010
Hypertension Research

Volume: 33, P: 1089
A comprehensive list of the Bunyavirales replication promoters reveals a unique promoter structure in Nairoviridae differing from other virus families

Yutaro Neriya
Shohei Kojima
Yusuke Matsumoto
ResearchOpen Access09 Aug 2022
Scientific Reports

Volume: 12, P: 1-10

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