Nature Search

Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis

Polyunsaturated fatty acids (PUFAs) are attracting considerable interest because of their diverse structures and properties. Now a method to access a wide array of PUFAs by full solid-phase synthesis has been developed and used to discover an anti-inflammatory fatty acid.

Yutaro Saito
Mayuko Akita
Shinsuke Sando
Research25 Jun 2025
Nature Chemistry

Volume: 17, P: 1391-1400
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

Jun Kunisawa
Makoto Arita
Hiroshi Kiyono
ResearchOpen Access11 Jun 2015
Scientific Reports

Volume: 5, P: 1-8
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Here, the authors inversely associate Blautia wexlerae with obesity and type 2 diabetes mellitus in humans and further show that administration of B. wexlerae to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial metabolism.

Koji Hosomi
Mayu Saito
Jun Kunisawa
ResearchOpen Access18 Aug 2022
Nature Communications

Volume: 13, P: 1-17
Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity

Koji Hosomi
Harumi Ohno
Jun Kunisawa
ResearchOpen Access28 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells

Yutaka Nakamura
Yozen Fuse
Koji Hase
ResearchOpen Access03 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

Takahiro Nagatake
Shigenobu Kishino
Jun Kunisawa
ResearchOpen Access10 Jan 2022
Mucosal Immunology

Volume: 15, P: 289-300
12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

Takahiro Nagatake
Yuki Shibata
Jun Kunisawa
ResearchOpen Access17 May 2021
Scientific Reports

Volume: 11, P: 1-11
Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

Hidehiko Suzuki
Takahiro Nagatake
Jun Kunisawa
ResearchOpen Access13 Feb 2018
Scientific Reports

Volume: 8, P: 1-9
BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses

Takahiro Nagatake
So-ichiro Hirata
Jun Kunisawa
ResearchOpen Access29 May 2019
Mucosal Immunology

Volume: 12, P: 1082-1091
High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells

Satoshi Nakamizo
Tetsuya Honda
Kenji Kabashima
ResearchOpen Access26 Oct 2017
Scientific Reports

Volume: 7, P: 1-13

Search

Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity

Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells

Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses

High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells

Search

Quick links

Search

Filter By:

Search

Quick links