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Showing 1–50 of 73 results

Advanced filters: Author: Takashi Kumagai Clear advanced filters

Atezolizumab following definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma – a multicenter phase 2 trial (EPOC1802)

Bando et al. perform a phase II trial of atezolizumab monotherapy following platinum-based definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma and report a complete response rate of 42%.

Hideaki Bando
Shogo Kumagai
Takashi Kojima
ResearchOpen Access19 Feb 2025
Nature Cancer

Volume: 6, P: 445-459
Chiral paddle-wheel diruthenium complexes for asymmetric catalysis

The development of chiral catalysts is of fundamental importance in asymmetric catalysis. Now, chiral paddle-wheel diruthenium complexes are reported that are stable under oxidizing conditions and effective in asymmetric C–C and C–N bond-forming reactions with turnover numbers of up to 1,880,000.

Taku Miyazawa
Takuro Suzuki
Shigeki Matsunaga
Research05 Oct 2020
Nature Catalysis

Volume: 3, P: 851-858
Force-induced tautomerization in a single molecule

Force-induced tautomerization in a single porphycene molecule is investigated on a Cu(110) surface at 5 K by using non-contact atomic force microscopy. The force needed to trigger the tautomerization process is quantified by force spectroscopy and theoretical calculations reveal the atomistic mechanism behind the reaction.

Janina N. Ladenthin
Thomas Frederiksen
Takashi Kumagai
Research04 Jul 2016
Nature Chemistry

Volume: 8, P: 935-940
Controlling intramolecular hydrogen transfer in a porphycene molecule with single atoms or molecules located nearby

The rate of an intramolecular hydrogen transfer reaction in a single porphycene molecule resting on a copper surface can be controlled by placing a copper adatom close to it. Cooperativity effects are also observed in rows of porphycene molecules, where the reaction rate of each individual molecule depends on the precise tautomer state of its neighbours.

Takashi Kumagai
Felix Hanke
Leonhard Grill
Research01 Dec 2013
Nature Chemistry

Volume: 6, P: 41-46
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
A compact X-ray free-electron laser emitting in the sub-ångström region

Researchers report sub-ångström fundamental-wavelength lasing at the SPring-8 Angstrom Compact Free-Electron Laser in Japan. The output has a maximum power of more than 10 GW, a pulse duration of 10⁻¹⁴ s and a lasing wavelength of 0.634 Å.

Tetsuya Ishikawa
Hideki Aoyagi
Noritaka Kumagai
Research24 Jun 2012
Nature Photonics

Volume: 6, P: 540-544
Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK, and a SRC family kinase

Hitoshi Takeda
Takashi Matozaki
Masato Kasuga
Research16 Jun 1998
Oncogene

Volume: 16, P: 3019-3027
Granulocyte abundance and maturation state at diagnosis predicts treatment-free remission in CML

Mikko Purhonen
Mikael Tatun
Oscar Brück
ResearchOpen Access16 Sept 2025
Leukemia

P: 1-10
Stage-specific GATA3 induction promotes ILC2 development after lineage commitment

The transcription factor GATA3 is enhanced in innate lymphoid type 2 cells (ILC2). Here the authors characterize the super enhancer regions of GATA3 and show that these enhancers are required to drive GATA3 expression and stage specific ILC2 development.

Hiroki Furuya
Yosuke Toda
Hiroshi Nakajima
ResearchOpen Access05 Jul 2024
Nature Communications

Volume: 15, P: 1-16
Erratum: A bacterial platform for fermentative production of plant alkaloids

Akira Nakagawa
Hiromichi Minami
Hidehiko Kumagai
Amendments and Corrections22 May 2012
Nature Communications

Volume: 3, P: 1
Land use change and El Niño-Southern Oscillation drive decadal carbon balance shifts in Southeast Asia

The carbon balance in Southeast Asia is highly uncertain. Here, the authors show that land use changes and occurrence of strong El Niño control decadal shifts in the carbon balance of this region.

Masayuki Kondo
Kazuhito Ichii
Christian Rödenbeck
ResearchOpen Access20 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Reconstitution of functional receptor for human interleukin-2 in mouse cells

Masanori Hatakeyama
Seijiro Minamoto
Tadatsugu Taniguchi
Research05 Dec 1985
Nature

Volume: 318, P: 467-470
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

Type 2 diabetes and obesity are associated with increased hepatic gluconeogenesis and lipogenesis, known as selective insulin resistance. Here Kubota et al. explain selective insulin resistance in the liver with the zonal distribution and selective insulin-mediated regulation of Irs1 and Irs2.

Naoto Kubota
Tetsuya Kubota
Takashi Kadowaki
ResearchOpen Access06 Oct 2016
Nature Communications

Volume: 7, P: 1-16
Thermal, Crystallization, and Biodegradation Behavior of Poly(3-hydroxybutyrate) Blends with Poly(butylene succinate-co-butylene adipate) and Poly(butylene succinate-co-ε-caprolactone)

Yong He
Takashi Masuda
Yoshio Inoue
Research01 Feb 1999
Polymer Journal

Volume: 31, P: 184-192
Efficacy of chemotherapy for patients with gastric cancer with early recurrence during or after adjuvant chemotherapy with S-1 alone: a multicenter retrospective study

Toshifumi Yamaguchi
Koshi Kumagai
Narikazu Boku
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Atomic-precision control of plasmon-induced single-molecule switching in a metal–semiconductor nanojunction

Single-molecule manipulation using light is essential for miniaturised optoelectronics. Here, the authors report the photoswitch of a molecule-silicon interface precisely tuned by 10-picometre-scale position control of a silver tip with localised plasmons.

Youngwook Park
Ikutaro Hamada
Akitoshi Shiotari
ResearchOpen Access07 Aug 2024
Nature Communications

Volume: 15, P: 1-9
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Macrophages can be divided into two subsets, M1 and M2, which have crucial differences in their function. Akira and colleagues identify the histone demethylase Jmjd3 as a key factor in M2 development.

Takashi Satoh
Osamu Takeuchi
Shizuo Akira
Research22 Aug 2010
Nature Immunology

Volume: 11, P: 936-944
Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function

Naoto Ujiie
Toru Nakano
Takashi Kamei
ResearchOpen Access12 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermentation in E. coli.

Akira Nakagawa
Eitaro Matsumura
Hiromichi Minami
ResearchOpen Access05 Feb 2016
Nature Communications

Volume: 7, P: 1-8
A bacterial platform for fermentative production of plant alkaloids

Secondary metabolites are widely used in human health and nutrition, but extraction yields from plants are often low. Nakagawaet al. have engineered the metabolism of Escherichia colito develop a fermentation system that produces plant alkaloids from simple carbon sources.

Akira Nakagawa
Hiromichi Minami
Hidehiko Kumagai
ResearchOpen Access24 May 2011
Nature Communications

Volume: 2, P: 1-9
Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

Yuki Maruyama
Yuichiro Nishimoto
Shinji Fukuda
ResearchOpen Access13 Jan 2022
Scientific Reports

Volume: 12, P: 1-9
Genome sequencing and analysis of Aspergillus oryzae

Masayuki Machida
Kiyoshi Asai
Hisashi Kikuchi
Research22 Dec 2005
Nature

Volume: 438, P: 1157-1161
Reduced dose of posttransplant cyclophosphamide in HLA-haploidentical peripheral blood stem cell transplantation

Junichi Sugita
Tomohiko Kamimura
Takanori Teshima
Research24 Sept 2020
Bone Marrow Transplantation

Volume: 56, P: 596-604
Comparison of oral microbiome profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water

Ryutaro Jo
Yuichiro Nishimoto
Shinji Fukuda
ResearchOpen Access06 Nov 2019
Scientific Reports

Volume: 9, P: 1-7
(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli

Akira Nakagawa
Chiaki Matsuzaki
Hiromichi Minami
ResearchOpen Access21 Oct 2014
Scientific Reports

Volume: 4, P: 1-8
Conversion of FeCo from soft to hard magnetic material by lattice engineering and nanopatterning

Takashi Hasegawa
Shunsuke Kanatani
Shunji Ishio
ResearchOpen Access16 Oct 2017
Scientific Reports

Volume: 7, P: 1-7
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Toshimasa Yamauchi
Yasunori Nio
Takashi Kadowaki
Research01 Feb 2007
Nature Medicine

Volume: 13, P: 332-339
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

Ionizing radiation damages small intestinal crypt cells, including epithelial stem cells and their progeny. Here the authors show that radiation-induced crypt cell death is amplified by the release of cellular RNA from apoptotic epithelial cells, which then triggers pro-apoptotic TLR3 signalling on neighbouring cells.

Naoki Takemura
Takumi Kawasaki
Satoshi Uematsu
ResearchOpen Access18 Mar 2014
Nature Communications

Volume: 5, P: 1-15
A compact free-electron laser for generating coherent radiation in the extreme ultraviolet region

Free-electron lasers can produce powerful pulses of radiation at very short wavelengths, even in the hard-X-ray region. In general, however, they comprise facilities several kilometres in length. A 55-m-long laser could open up the technology to a broader range of researchers.

Tsumoru Shintake
Hitoshi Tanaka
Tetsuya Ishikawa
Research27 Jul 2008
Nature Photonics

Volume: 2, P: 555-559
Sub-molecular diagnostics of coherent energy transfer

Sub-molecular spectroscopy enables the real-space study of incoherent and coherent electronic energy transfer in artificial molecular donor–acceptor systems and their dependence on the molecular arrangement.

Takashi Kumagai
News & Views14 Jul 2022
Nature Nanotechnology

Volume: 17, P: 674-675
Basophils are required for the induction of Th2 immunity to haptens and peptide antigens

Both dendritic cells and basophils have been shown to influence T helper 2 cell induction, however the relative importance of their roles remains unclear. Otsuka et al. find that basophils present hapten and peptide antigens to T cells, but are unable to present protein antigens in the absence of dendritic cells.

Atsushi Otsuka
Saeko Nakajima
Kenji Kabashima
ResearchOpen Access23 Apr 2013
Nature Communications

Volume: 4, P: 1-9
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Suppression of Catechol-O-Methyltransferase Activity through Blunting of α₂-Adrenoceptor Can Explain Hypertension in Dahl Salt-Sensitive Rats

Yoko Hirano
Makoto Tsunoda
Takashi Funatsu
Research01 Mar 2007
Hypertension Research

Volume: 30, P: 269-278
Photoconductivity of a Polyimide with an Alicyclic Diamine Doped with N,N,N′N′-Tetramethyl-p-phenylenediamine

Sung Ae Lee
Takashi Yamashita
Kazuyuki Horie
Research01 Sept 1997
Polymer Journal

Volume: 29, P: 752-758
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism

Endoplasmic reticulum (ER) stress has been proposed to play a role in metabolic diseases. Here, Sasako and colleagues identify stromal cell-derived factor 2 like 1 (Sdf2l1) as a regulator of the ER stress response to feeding in the liver, and suggest that its downregulation may promote diabetes and hepatic steatosis in humans.

Takayoshi Sasako
Mitsuru Ohsugi
Kohjiro Ueki
ResearchOpen Access27 Feb 2019
Nature Communications

Volume: 10, P: 1-16
Sub-molecular photoluminescence

Photoluminescence spectroscopy using atomic-scale light reveals an optical transition of a single molecule at sub-nanometre resolution.

Takashi Kumagai
News & Views19 Oct 2020
Nature Photonics

Volume: 14, P: 653-655
Reevaluating the therapeutic role of extended lymph node dissection in the era of robot-assisted radical prostatectomy

Atsuro Sawada
Koshiro Nishimoto
Takahiro Inoue
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-13
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

The zinc finger protein Zc3h12a is identified as a ribonuclease that inhibits autoimmune disorders by controlling the degradation of messenger RNAs encoding proinflammatory cytokines.

Kazufumi Matsushita
Osamu Takeuchi
Shizuo Akira
Research25 Mar 2009
Nature

Volume: 458, P: 1185-1190
The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

Sensing of nutrient status coordinates the regulation of liver glucose and lipid metabolism, and is important for metabolic homeostasis. Here the authors report that transcriptional the corepressor CtBP2 can sense nutrient status and coordinate repression of liver glucose and lipid metabolism via Fox01 and SREBP1, respectively.

Motohiro Sekiya
Kenta Kainoh
Hitoshi Shimano
ResearchOpen Access02 Nov 2021
Nature Communications

Volume: 12, P: 1-19
Seismic seiche-related oscillations in Lake Biwa, Japan, after the 2011 Tohoku earthquake

Maho Iwaki
Takashi Toda
ResearchOpen Access11 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
A survey on awareness of genetic counseling for non-invasive prenatal testing: the first year experience in Japan

Junko Yotsumoto
Akihiko Sekizawa
Norimasa Sawaguchi
Research08 Sept 2016
Journal of Human Genetics

Volume: 61, P: 995-1001
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

The stability of interleukin 6 transcripts is negatively regulated by the RNAse regnase-1. Akira and colleagues show that regnase-1 is targeted for degradation by phosphorylation mediated by the kinase IKK, which allows more interleukin 6 production.

Hidenori Iwasaki
Osamu Takeuchi
Shizuo Akira
Research30 Oct 2011
Nature Immunology

Volume: 12, P: 1167-1175
Determination of key residues in MRGPRX2 to enhance pseudo-allergic reactions induced by fluoroquinolones

Eri Hamamura-Yasuno
Junya Matsushita
Kazuhiko Mori
ResearchOpen Access22 Apr 2022
Scientific Reports

Volume: 12, P: 1-9
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Enhanced Z-isomerization of tomato lycopene through the optimal combination of food ingredients

Masaki Honda
Hakuto Kageyama
Tetsuya Fukaya
ResearchOpen Access28 May 2019
Scientific Reports

Volume: 9, P: 1-7
Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Takamitsu Unoki
Yumi Abiko
Yoshito Kumagai
ResearchOpen Access30 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Experimental demonstration of robust entanglement distribution over reciprocal noisy channels assisted by a counter-propagating classical reference light

Rikizo Ikuta
Shota Nozaki
Nobuyuki Imoto
ResearchOpen Access06 Jul 2017
Scientific Reports

Volume: 7, P: 1-7
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

Haematopoietic expression of the adaptor protein Trib1 is shown to be required for the presence of adipose-tissue-resident macrophages with an M2-like phenotype; Trib1 deficiency leads to aberrant expression of C/EBPα and impaired adipose tissue function.

Takashi Satoh
Hiroyasu Kidoya
Shizuo Akira
Research20 Mar 2013
Nature

Volume: 495, P: 524-528

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