Nature Search

Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes

A genetic study in over 300,000 males reveals that Y chromosome loss affects type 2 diabetes risk differently in East Asians and Europeans. Multi-omics data suggest that this may be due to impaired glucose metabolism in Y-deficient pancreatic β cells.

Go Sato
Yuji Yamamoto
Yukinori Okada
ResearchOpen Access23 Feb 2026
Nature Medicine

P: 1-12
Large surface relaxation in the organic semiconductor tetracene

Interfacial charge transport determines the performance of organic semiconductors, yet the surface influence is poorly understood. Here, Morisaki et al.observe surface relaxation and its resulting transport properties in the first monolayer of tetracene, which are dissimilar to those of the bulk.

Hazuki Morisaki
Takashi Koretsune
Yusuke Wakabayashi
Research07 Nov 2014
Nature Communications

Volume: 5, P: 1-6
A cross-population compendium of gene–environment interactions

A large cross-population atlas of gene–environment interactions reveals how age, sex and lifestyle shape genetic effects, heritability, prediction accuracy and disease biology, with implications for personalized medicine and drug development.

Shinichi Namba
Kyuto Sonehara
Yukinori Okada
ResearchOpen Access28 Jan 2026
Nature

P: 1-10
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases

Here, the authors perform cross-trait analyses of respiratory and cardiometabolic diseases, rheumatoid arthritis, and smoking and identify negative genetic correlations between respiratory and cardiometabolic diseases in individuals of East Asian ancestry, in opposition from the positive association in European ancestry individuals.

Yuji Yamamoto
Yuya Shirai
Yukinori Okada
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations

Using biobank data from over 250,000 participants, the authors present a detailed picture of regional and individual variation in the tripartite ancestral structure of modern Japanese populations and demonstrate its impact on elevated body mass index.

Kenichi Yamamoto
Shinichi Namba
Yukinori Okada
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-15
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss

Here, the authors perform a genome-wide association study for recurrent pregnancy loss without apparent clinical causes and identify a protective HLA haplotype. They also show that rare predicted loss-of-function variants in CDH11 are associated with risk of recurrent pregnancy loss.

Kyuto Sonehara
Yoshitaka Yano
Mayumi Sugiura-Ogasawara
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-9
Neoantigens elicit T cell responses in breast cancer

Takafumi Morisaki
Makoto Kubo
Masafumi Nakamura
ResearchOpen Access30 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Lipopolysaccharide increases cyclo-oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-κB activation

Masayuki Kojima
Takashi Morisaki
Masao Tanaka
Research07 Mar 2000
Oncogene

Volume: 19, P: 1225-1231
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9

Yuta Morisaki
Mamiko Niikura
Hidemi Misawa
ResearchOpen Access06 Jun 2016
Scientific Reports

Volume: 6, P: 1-19
Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma

Shoichi Nakamura
Kenoki Ohuchida
Masafumi Nakamura
Research21 Aug 2023
British Journal of Cancer

Volume: 129, P: 1314-1326
Interferon-γ suppresses transforming growth factor-β-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model

Hirotaka Kuga
Takashi Morisaki
Mitsuo Katano
Research30 Oct 2003
Oncogene

Volume: 22, P: 7838-7847
PSK-mediated NF-κB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1

Hao Zhang
Takashi Morisaki
Mitsuo Katano
Research10 Apr 2003
Oncogene

Volume: 22, P: 2088-2096
The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death

Shinji Kuninaka
Masanobu Nomura
Hideyuki Saya
Research27 Jun 2005
Oncogene

Volume: 24, P: 5287-5298
Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

Tomofuji et al. perform non-targeted metabolomics on serum samples from people with type 2 diabetes with or without complications. The authors identify metabolites associated with retinal and renal complications.

Yoshihiko Tomofuji
Ken Suzuki
Takashi Kadowaki
ResearchOpen Access09 Jan 2023
Communications Medicine

Volume: 3, P: 1-8

Search

Host control of persistent Epstein–Barr virus infection

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes

Large surface relaxation in the organic semiconductor tetracene

A cross-population compendium of gene–environment interactions

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Mapping the human genetic architecture of COVID-19

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations

A second update on mapping the human genetic architecture of COVID-19

Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss

Neoantigens elicit T cell responses in breast cancer

Lipopolysaccharide increases cyclo-oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-κB activation

Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9

Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma

Interferon-γ suppresses transforming growth factor-β-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model

PSK-mediated NF-κB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1

The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

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