SOX2 is expressed frequently in small cell lung cancer (SCLC). ASCL1 is a potent driver of SOX2 expression and regulates INSM1 expression in the major subtype, SCLC-A (ASCL1). However, SOX2 also regulates distinct genes in the hippo pathway in the minor subtype SCLC-Y (YAP1). These results show that ASCL1-SOX2 axis is a potential therapeutic target in SCLC.
- Yuki Tenjin
- Kumi Matsuura
- Takaaki Ito
