The authors show that EBV-encoded oncoprotein LMP1 up-regulates cyclin-dependent kinase 1 (CDK1) and survivin expression in nasal NK/T-cell lymphoma (NNKTL). CDK1 and survivin inhibitors, including mithramycin, reduce the proliferation of NNKTL cells. Mithramycin further induces anti-tumor effects in an NNKTL xenograft mouse model. These results suggest that CDK1 and survivin may be potential therapeutic targets for NNKTL.
- Toshihiro Nagato
- Seigo Ueda
- Yasuaki Harabuchi